Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats
The Inner Mongolia cashmere goat is a local breed valued for both its cashmere and meat production. Early growth traits include birth weight and weaning weight. Generally, cashmere goats with higher birth and weaning weights tend to exhibit a higher carcass weight at slaughter. Consequently, explori...
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2025-02-01
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| author | Youjun Rong Xiaofang Ao Furong Guo Xinle Wang Mingxuan Han Lu Zhang Qincheng Xia Fangzheng Shang Qi Lv Zhiying Wang Rui Su Yanhong Zhao Yanjun Zhang Ruijun Wang |
| author_facet | Youjun Rong Xiaofang Ao Furong Guo Xinle Wang Mingxuan Han Lu Zhang Qincheng Xia Fangzheng Shang Qi Lv Zhiying Wang Rui Su Yanhong Zhao Yanjun Zhang Ruijun Wang |
| author_sort | Youjun Rong |
| collection | DOAJ |
| description | The Inner Mongolia cashmere goat is a local breed valued for both its cashmere and meat production. Early growth traits include birth weight and weaning weight. Generally, cashmere goats with higher birth and weaning weights tend to exhibit a higher carcass weight at slaughter. Consequently, exploring the genetic variation associated with these early growth traits is crucial in enhancing the meat production performance of Inner Mongolia cashmere goats. For this study, we performed genome-wide association analysis and haplotype analysis on the early growth traits of 212 Inner Mongolia cashmere goats (72 rams, 140 ewes) to identify molecular markers and haplotypes significantly associated with birth and weaning weights. Through genome-wide association analysis and gene annotation, we identified 21 SNPs and 117 candidate genes linked to early growth traits. Notably, genes such as <i>RUNX1T1</i>, <i>ERBIN</i>, <i>MYO15B</i>, <i>NT5C</i>, <i>GRB2</i>, <i>ITGB4</i>, and <i>GALK</i> emerged as significant factors influencing the early growth of Inner Mongolia cashmere goats. Additionally, nine haplotype blocks related to early growth traits were constructed, resulting in eight haplotype combinations. In conclusion, the haplotype combinations A1A1, C1C1, and D1D1 were found to be beneficial for the genetic improvement of early growth traits in Inner Mongolia cashmere goats. |
| format | Article |
| id | doaj-art-c1ef96f51c7e4378978def84236c8f21 |
| institution | Kabale University |
| issn | 2306-7381 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj-art-c1ef96f51c7e4378978def84236c8f212025-08-20T03:44:01ZengMDPI AGVeterinary Sciences2306-73812025-02-0112319210.3390/vetsci12030192Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere GoatsYoujun Rong0Xiaofang Ao1Furong Guo2Xinle Wang3Mingxuan Han4Lu Zhang5Qincheng Xia6Fangzheng Shang7Qi Lv8Zhiying Wang9Rui Su10Yanhong Zhao11Yanjun Zhang12Ruijun Wang13College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaScience and Technology Development Center of Ulanqab, Ulanqab 012000, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, ChinaThe Inner Mongolia cashmere goat is a local breed valued for both its cashmere and meat production. Early growth traits include birth weight and weaning weight. Generally, cashmere goats with higher birth and weaning weights tend to exhibit a higher carcass weight at slaughter. Consequently, exploring the genetic variation associated with these early growth traits is crucial in enhancing the meat production performance of Inner Mongolia cashmere goats. For this study, we performed genome-wide association analysis and haplotype analysis on the early growth traits of 212 Inner Mongolia cashmere goats (72 rams, 140 ewes) to identify molecular markers and haplotypes significantly associated with birth and weaning weights. Through genome-wide association analysis and gene annotation, we identified 21 SNPs and 117 candidate genes linked to early growth traits. Notably, genes such as <i>RUNX1T1</i>, <i>ERBIN</i>, <i>MYO15B</i>, <i>NT5C</i>, <i>GRB2</i>, <i>ITGB4</i>, and <i>GALK</i> emerged as significant factors influencing the early growth of Inner Mongolia cashmere goats. Additionally, nine haplotype blocks related to early growth traits were constructed, resulting in eight haplotype combinations. In conclusion, the haplotype combinations A1A1, C1C1, and D1D1 were found to be beneficial for the genetic improvement of early growth traits in Inner Mongolia cashmere goats.https://www.mdpi.com/2306-7381/12/3/192Inner Mongolia cashmere goatsgenome-wide association analysisbirth weightweaning weighthaplotype |
| spellingShingle | Youjun Rong Xiaofang Ao Furong Guo Xinle Wang Mingxuan Han Lu Zhang Qincheng Xia Fangzheng Shang Qi Lv Zhiying Wang Rui Su Yanhong Zhao Yanjun Zhang Ruijun Wang Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats Veterinary Sciences Inner Mongolia cashmere goats genome-wide association analysis birth weight weaning weight haplotype |
| title | Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats |
| title_full | Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats |
| title_fullStr | Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats |
| title_full_unstemmed | Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats |
| title_short | Genome-Wide Association Analysis Revealed Candidate Genes Related to Early Growth Traits in Inner Mongolia Cashmere Goats |
| title_sort | genome wide association analysis revealed candidate genes related to early growth traits in inner mongolia cashmere goats |
| topic | Inner Mongolia cashmere goats genome-wide association analysis birth weight weaning weight haplotype |
| url | https://www.mdpi.com/2306-7381/12/3/192 |
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