EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW
Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literat...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Sriwijaya
2025-01-01
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| Series: | Jurnal Kedokteran dan Kesehatan |
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| Online Access: | https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/453 |
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| author | Khairunnisa Rizqika Amanda Putri Evi Lusiana Theodorus Ayeshah Augusta Rosdah Debby Handayati Harahap Veny Larasati |
| author_facet | Khairunnisa Rizqika Amanda Putri Evi Lusiana Theodorus Ayeshah Augusta Rosdah Debby Handayati Harahap Veny Larasati |
| author_sort | Khairunnisa Rizqika Amanda Putri |
| collection | DOAJ |
| description | Exposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms. |
| format | Article |
| id | doaj-art-c1ec8aa1cbbe47fb83e1bf19abbd5922 |
| institution | DOAJ |
| issn | 2406-7431 2614-0411 |
| language | Indonesian |
| publishDate | 2025-01-01 |
| publisher | Universitas Sriwijaya |
| record_format | Article |
| series | Jurnal Kedokteran dan Kesehatan |
| spelling | doaj-art-c1ec8aa1cbbe47fb83e1bf19abbd59222025-08-20T03:16:38ZindUniversitas SriwijayaJurnal Kedokteran dan Kesehatan2406-74312614-04112025-01-01121212910.32539/jkk.v12i1.453453EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEWKhairunnisa Rizqika Amanda Putri0Evi Lusiana1Theodorus2Ayeshah Augusta Rosdah3Debby Handayati Harahap4Veny Larasati5Biomedical Science Master’s Study Program, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaDepartment of Pharmacology, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaDepartment of Pharmacology, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaDepartment of Pharmacology, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaDepartment of Pharmacology, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaDepartment of Histology, Faculty of Medicine, University of Sriwijaya, Palembang, IndonesiaExposure to free radicals can cause hepatotoxicity in liver cells. Hepatoprotectors are needed to prevent free radicals. The flavonoid group anthocyanin compounds, which give many plants purple, blue, and red colors, have antioxidant activity as hepatoprotectors. This study uses a systematic literature review to review the effectiveness of various plants containing anthocyanins as hepatoprotectors. Articles were searched using Google Scholar, PubMed, and NCBI with keywords such as "Anthocyanin compounds and Hepatoprotective effects" that met the inclusion and exclusion criteria. The results obtained from 7 review articles show that several plants contain anthocyanins, such as bilberry and blackberry, Rosella, purple cabbage, butterfly pea flower, Aronia melanocarpa Elliot (AMA), red cabbage, and radish. The mechanisms in plants containing anthocyanins as hepatoprotective include antioxidant activity, inhibition of cytochrome enzymes, inhibition of inflammation, protein expression, and modulation of the apoptotic signal pathway. This review concludes that plants containing anthocyanins are effective as natural hepatoprotectors with various mechanisms.https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/453anthocyaninliver disorderhepatoprotector |
| spellingShingle | Khairunnisa Rizqika Amanda Putri Evi Lusiana Theodorus Ayeshah Augusta Rosdah Debby Handayati Harahap Veny Larasati EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW Jurnal Kedokteran dan Kesehatan anthocyanin liver disorder hepatoprotector |
| title | EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW |
| title_full | EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW |
| title_fullStr | EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW |
| title_full_unstemmed | EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW |
| title_short | EFFECTIVENESS OF ANTHOCYANIN AS A HEPATOPROTECTOR: A SYSTEMATIC LITERATURE REVIEW |
| title_sort | effectiveness of anthocyanin as a hepatoprotector a systematic literature review |
| topic | anthocyanin liver disorder hepatoprotector |
| url | https://jkk-fk.ejournal.unsri.ac.id/index.php/jkk/article/view/453 |
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