Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study
Active drug delivery systems for cancer therapy are gaining attention for their biocompatibility and enhanced efficacy compared to conventional chemotherapy and surgery. To improve precision in targeted drug delivery (TDD), actuating devices using external magnetic fields are employed. However, a ke...
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MDPI AG
2025-01-01
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| author | Chan Kim Jiyun Nan Kim Tien Nguyen Jong-Oh Park Eunpyo Choi Jayoung Kim |
| author_facet | Chan Kim Jiyun Nan Kim Tien Nguyen Jong-Oh Park Eunpyo Choi Jayoung Kim |
| author_sort | Chan Kim |
| collection | DOAJ |
| description | Active drug delivery systems for cancer therapy are gaining attention for their biocompatibility and enhanced efficacy compared to conventional chemotherapy and surgery. To improve precision in targeted drug delivery (TDD), actuating devices using external magnetic fields are employed. However, a key challenge is the inability to visually track magnetic drug carriers in blood vessels, complicating navigation to the target. Magnetic particle imaging (MPI) systems can localize magnetic carriers (MCs) but rely on bulky electromagnetic coils to generate a static magnetic field gradient, creating a field-free point (FFP) within the field of view (FOV). Also, additional coils are required to move the FFP across the FOV, limiting flexibility and increasing the system size. To address these issues, we propose a non-FFP-based, open-type RF coil system with a simplified structure composed of a Tx/Rx coil and a permanent magnet at the coil center, eliminating the need for an FFP. Furthermore, integrating a robotic arm for coil assembly enables easy adjustment of the FOV size and location. Finally, imaging tests with magnetic nanoparticles (MNPs) confirmed the system’s ability to detect and localize a minimum mass of 0.3 mg (Fe) in 80 × 80 mm<sup>2</sup>. |
| format | Article |
| id | doaj-art-c1e5445e496b4003b4e575b6afa09508 |
| institution | OA Journals |
| issn | 1424-8220 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Sensors |
| spelling | doaj-art-c1e5445e496b4003b4e575b6afa095082025-08-20T02:12:33ZengMDPI AGSensors1424-82202025-01-0125366510.3390/s25030665Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility StudyChan Kim0Jiyun Nan1Kim Tien Nguyen2Jong-Oh Park3Eunpyo Choi4Jayoung Kim5Korea Institute of Medical Microrobotics, Gwangju 61186, Republic of KoreaSchool of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of KoreaKorea Institute of Medical Microrobotics, Gwangju 61186, Republic of KoreaKorea Institute of Medical Microrobotics, Gwangju 61186, Republic of KoreaSchool of Mechanical Engineering, Chonnam National University, Gwangju 61186, Republic of KoreaDepartment of Biosystems Engineering, Chungbuk National University, Cheongju 28644, Republic of KoreaActive drug delivery systems for cancer therapy are gaining attention for their biocompatibility and enhanced efficacy compared to conventional chemotherapy and surgery. To improve precision in targeted drug delivery (TDD), actuating devices using external magnetic fields are employed. However, a key challenge is the inability to visually track magnetic drug carriers in blood vessels, complicating navigation to the target. Magnetic particle imaging (MPI) systems can localize magnetic carriers (MCs) but rely on bulky electromagnetic coils to generate a static magnetic field gradient, creating a field-free point (FFP) within the field of view (FOV). Also, additional coils are required to move the FFP across the FOV, limiting flexibility and increasing the system size. To address these issues, we propose a non-FFP-based, open-type RF coil system with a simplified structure composed of a Tx/Rx coil and a permanent magnet at the coil center, eliminating the need for an FFP. Furthermore, integrating a robotic arm for coil assembly enables easy adjustment of the FOV size and location. Finally, imaging tests with magnetic nanoparticles (MNPs) confirmed the system’s ability to detect and localize a minimum mass of 0.3 mg (Fe) in 80 × 80 mm<sup>2</sup>.https://www.mdpi.com/1424-8220/25/3/665targeted drug deliverymagnetic particle imagingnon-FFP-based methodopen-type MPI scanner |
| spellingShingle | Chan Kim Jiyun Nan Kim Tien Nguyen Jong-Oh Park Eunpyo Choi Jayoung Kim Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study Sensors targeted drug delivery magnetic particle imaging non-FFP-based method open-type MPI scanner |
| title | Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study |
| title_full | Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study |
| title_fullStr | Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study |
| title_full_unstemmed | Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study |
| title_short | Non-FFP-Based Magnetic Particle Imaging (NFMPI) with an Open-Type RF Coil System: A Feasibility Study |
| title_sort | non ffp based magnetic particle imaging nfmpi with an open type rf coil system a feasibility study |
| topic | targeted drug delivery magnetic particle imaging non-FFP-based method open-type MPI scanner |
| url | https://www.mdpi.com/1424-8220/25/3/665 |
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