Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer

Hyptolide induces ER stress-mediated cell death and enhances GSK3β-regulated cisplatin chemosensitivity in ovarian cancer

Abstract Background Ovarian cancer is a highly prevalent cancer among women with a high risk for relapse and drug resistance. Seventy eight percent of women diagnosed with ovarian cancer live for at least one year after diagnosis. Hyptolide, a natural compound, has been shown to act as an anti-infla...

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Bibliographic Details
Main Authors: Yusi Luluk Rahmania, Person Pesona Renta, Damar Nurwahyu Bima, Yu-Shan Lin, Ngoc Thang Nguyen, Pin-Yu Wang, Meiny Suzery, Wen-Tai Chiu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Ovarian Research
Subjects:
Hyptolide
Ovarian cancer
Chemoresistant
ER stress
GSK3β
β-catenin
Online Access:https://doi.org/10.1186/s13048-025-01712-4
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