Heart Failure and Gut Microbiota: What Is Cause and Effect?
Emerging evidence highlights the central role of gut microbiota in maintaining physiological homeostasis within the host. Disruptions in gut microbiota can destabilize systemic metabolism and inflammation, driving the onset and progression of cardiometabolic diseases. In heart failure (HF), intestin...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS)
2025-01-01
|
| Series: | Research |
| Online Access: | https://spj.science.org/doi/10.34133/research.0610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849718578553552896 |
|---|---|
| author | Shichun Shen Beiduo Tian Haizhu Zhang Yu-Chen Wang Tao Li Yang Cao |
| author_facet | Shichun Shen Beiduo Tian Haizhu Zhang Yu-Chen Wang Tao Li Yang Cao |
| author_sort | Shichun Shen |
| collection | DOAJ |
| description | Emerging evidence highlights the central role of gut microbiota in maintaining physiological homeostasis within the host. Disruptions in gut microbiota can destabilize systemic metabolism and inflammation, driving the onset and progression of cardiometabolic diseases. In heart failure (HF), intestinal dysfunction may induce the release of endotoxins and metabolites, leading to dysbiosis and exacerbating HF through the gut–heart axis. Understanding the relationship between gut microbiota and HF offers critical insights into disease mechanisms and therapeutic opportunities. Current research highlights promising potential to improve patient outcomes by restoring microbiota balance. In this review, we summarize the current studies in understanding the gut microbiota–HF connection and discuss avenues for future investigation. |
| format | Article |
| id | doaj-art-c1e2a0b5bb6e457e941c246e9dd338bb |
| institution | DOAJ |
| issn | 2639-5274 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | Article |
| series | Research |
| spelling | doaj-art-c1e2a0b5bb6e457e941c246e9dd338bb2025-08-20T03:12:20ZengAmerican Association for the Advancement of Science (AAAS)Research2639-52742025-01-01810.34133/research.0610Heart Failure and Gut Microbiota: What Is Cause and Effect?Shichun Shen0Beiduo Tian1Haizhu Zhang2Yu-Chen Wang3Tao Li4Yang Cao5Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China.Department of Medicine, Division of Cardiology, Department of Microbiology, Immunology and Molecular Genetics, and Department of Human Genetics, University of California, Los Angeles, CA, USA.Department of Anesthesiology, Laboratory of Mitochondrial Metabolism and Perioperative Medicine, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China.Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.Emerging evidence highlights the central role of gut microbiota in maintaining physiological homeostasis within the host. Disruptions in gut microbiota can destabilize systemic metabolism and inflammation, driving the onset and progression of cardiometabolic diseases. In heart failure (HF), intestinal dysfunction may induce the release of endotoxins and metabolites, leading to dysbiosis and exacerbating HF through the gut–heart axis. Understanding the relationship between gut microbiota and HF offers critical insights into disease mechanisms and therapeutic opportunities. Current research highlights promising potential to improve patient outcomes by restoring microbiota balance. In this review, we summarize the current studies in understanding the gut microbiota–HF connection and discuss avenues for future investigation.https://spj.science.org/doi/10.34133/research.0610 |
| spellingShingle | Shichun Shen Beiduo Tian Haizhu Zhang Yu-Chen Wang Tao Li Yang Cao Heart Failure and Gut Microbiota: What Is Cause and Effect? Research |
| title | Heart Failure and Gut Microbiota: What Is Cause and Effect? |
| title_full | Heart Failure and Gut Microbiota: What Is Cause and Effect? |
| title_fullStr | Heart Failure and Gut Microbiota: What Is Cause and Effect? |
| title_full_unstemmed | Heart Failure and Gut Microbiota: What Is Cause and Effect? |
| title_short | Heart Failure and Gut Microbiota: What Is Cause and Effect? |
| title_sort | heart failure and gut microbiota what is cause and effect |
| url | https://spj.science.org/doi/10.34133/research.0610 |
| work_keys_str_mv | AT shichunshen heartfailureandgutmicrobiotawhatiscauseandeffect AT beiduotian heartfailureandgutmicrobiotawhatiscauseandeffect AT haizhuzhang heartfailureandgutmicrobiotawhatiscauseandeffect AT yuchenwang heartfailureandgutmicrobiotawhatiscauseandeffect AT taoli heartfailureandgutmicrobiotawhatiscauseandeffect AT yangcao heartfailureandgutmicrobiotawhatiscauseandeffect |