Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis

Talc pleurodesis, a frequently performed procedure for refractory pneumothorax or pleural effusion, induces chronic granulomatous inflammation. It can present years later with pleural thickening and markedly increased uptake on positron emission tomography/computed tomography (PET/CT), mimicking the...

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Main Authors: Supriya A. Bhupathy, Tung V. Huynh
Format: Article
Language:English
Published: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-12-01
Series:World Journal of Nuclear Medicine
Subjects:
Online Access:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750394
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author Supriya A. Bhupathy
Tung V. Huynh
author_facet Supriya A. Bhupathy
Tung V. Huynh
author_sort Supriya A. Bhupathy
collection DOAJ
description Talc pleurodesis, a frequently performed procedure for refractory pneumothorax or pleural effusion, induces chronic granulomatous inflammation. It can present years later with pleural thickening and markedly increased uptake on positron emission tomography/computed tomography (PET/CT), mimicking the presentation of malignancies. We present the case of a 63-year-old female with positive 18F-fluorodeoxyglucose PET/CT 20 years after talc pleurodesis. Malignancy such as mesothelioma could not initially be ruled out. CT-guided biopsy confirmed an extensive foreign-body giant-cell reaction consistent with talc-related inflammatory change. This case highlights the need for the consideration of talcoma in the differential diagnosis of patients who undergo talc pleurodesis, and is unique in the significant timespan of 20 years between pleurodesis and positive imaging findings.
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spelling doaj-art-c1df3331dfaf438b8dcf7859294d10e82025-08-20T02:54:36ZengThieme Medical and Scientific Publishers Pvt. Ltd.World Journal of Nuclear Medicine1450-11471607-33122022-12-01210432532810.1055/s-0042-1750394Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc PleurodesisSupriya A. Bhupathy0Tung V. Huynh1Department of Medical Education, California University of Science and Medicine, Colton, California, United StatesDepartment of Medical Imaging, Arrowhead Regional Medical Center, Colton, California, United StatesTalc pleurodesis, a frequently performed procedure for refractory pneumothorax or pleural effusion, induces chronic granulomatous inflammation. It can present years later with pleural thickening and markedly increased uptake on positron emission tomography/computed tomography (PET/CT), mimicking the presentation of malignancies. We present the case of a 63-year-old female with positive 18F-fluorodeoxyglucose PET/CT 20 years after talc pleurodesis. Malignancy such as mesothelioma could not initially be ruled out. CT-guided biopsy confirmed an extensive foreign-body giant-cell reaction consistent with talc-related inflammatory change. This case highlights the need for the consideration of talcoma in the differential diagnosis of patients who undergo talc pleurodesis, and is unique in the significant timespan of 20 years between pleurodesis and positive imaging findings.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750394positron emission tomographycomputed tomography 18f-fluorodeoxyglucosetalc pleurodesispneumothorax
spellingShingle Supriya A. Bhupathy
Tung V. Huynh
Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
World Journal of Nuclear Medicine
positron emission tomography
computed tomography
18f-fluorodeoxyglucose
talc pleurodesis
pneumothorax
title Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
title_full Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
title_fullStr Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
title_full_unstemmed Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
title_short Positive 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography 20 Years after Talc Pleurodesis
title_sort positive 18f fluorodeoxyglucose positron emission tomography computed tomography 20 years after talc pleurodesis
topic positron emission tomography
computed tomography
18f-fluorodeoxyglucose
talc pleurodesis
pneumothorax
url http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750394
work_keys_str_mv AT supriyaabhupathy positive18ffluorodeoxyglucosepositronemissiontomographycomputedtomography20yearsaftertalcpleurodesis
AT tungvhuynh positive18ffluorodeoxyglucosepositronemissiontomographycomputedtomography20yearsaftertalcpleurodesis