Topical Impact of Nanosimvastatin on Bone Fracture
Bone healing is a vert complex process. Fracture healing is a major challenge in orthopaedic practice and research. Simvastatin is an encouraging novel bone regeneration inducer due to its safety, low cost, and clinical convenience. However, the specific mechanism of simvastatin's effect on bo...
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2025-06-01
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| Series: | Dentistry 3000 |
| Online Access: | http://dentistry3000.pitt.edu/ojs/dentistry3000/article/view/861 |
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| author | Luay H. Jalil |
| author_facet | Luay H. Jalil |
| author_sort | Luay H. Jalil |
| collection | DOAJ |
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Bone healing is a vert complex process. Fracture healing is a major challenge in orthopaedic practice and research. Simvastatin is an encouraging novel bone regeneration inducer due to its safety, low cost, and clinical convenience. However, the specific mechanism of simvastatin's effect on bone growth, as well as the best dose, are unknown. Simvastatin is a biodegradable polymer that promotes bone growth. A total number of 16 adult albino rabbits were divided into two groups (8 rabbits /each). A defect was done in bone and filled with gel only for controls and treatment specimens were filled with nanoliposomal simvastatin. The results showed that the treatment group with nanosimvastatin gel had a significant improvement in bone healing compared to the control group.
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| format | Article |
| id | doaj-art-c1dc06cc73b04db9a4cf1b34262408d6 |
| institution | OA Journals |
| issn | 2167-8677 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Dentistry 3000 |
| spelling | doaj-art-c1dc06cc73b04db9a4cf1b34262408d62025-08-20T02:34:54ZengUniversity Library System, University of PittsburghDentistry 30002167-86772025-06-0113110.5195/d3000.2025.861Topical Impact of Nanosimvastatin on Bone FractureLuay H. Jalil0College of Dentistry, Al-Farahidi University, Baghdad, Iraq Bone healing is a vert complex process. Fracture healing is a major challenge in orthopaedic practice and research. Simvastatin is an encouraging novel bone regeneration inducer due to its safety, low cost, and clinical convenience. However, the specific mechanism of simvastatin's effect on bone growth, as well as the best dose, are unknown. Simvastatin is a biodegradable polymer that promotes bone growth. A total number of 16 adult albino rabbits were divided into two groups (8 rabbits /each). A defect was done in bone and filled with gel only for controls and treatment specimens were filled with nanoliposomal simvastatin. The results showed that the treatment group with nanosimvastatin gel had a significant improvement in bone healing compared to the control group. http://dentistry3000.pitt.edu/ojs/dentistry3000/article/view/861 |
| spellingShingle | Luay H. Jalil Topical Impact of Nanosimvastatin on Bone Fracture Dentistry 3000 |
| title | Topical Impact of Nanosimvastatin on Bone Fracture |
| title_full | Topical Impact of Nanosimvastatin on Bone Fracture |
| title_fullStr | Topical Impact of Nanosimvastatin on Bone Fracture |
| title_full_unstemmed | Topical Impact of Nanosimvastatin on Bone Fracture |
| title_short | Topical Impact of Nanosimvastatin on Bone Fracture |
| title_sort | topical impact of nanosimvastatin on bone fracture |
| url | http://dentistry3000.pitt.edu/ojs/dentistry3000/article/view/861 |
| work_keys_str_mv | AT luayhjalil topicalimpactofnanosimvastatinonbonefracture |