Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index
The aim of the study was to assess the course of epilepsy in patients with signs of cranio-cerebral imbalance with a low CSF-cranial index.Materials and methods. We conducted a prospective analysis of clinical, instrumental and laboratory data from the case histories of 78 patients with epileptic se...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2018-11-01
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| Series: | Эпилепсия и пароксизмальные состояния |
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| Online Access: | https://www.epilepsia.su/jour/article/view/425 |
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| author | V. I. Larkin N. S. Stelmakh |
| author_facet | V. I. Larkin N. S. Stelmakh |
| author_sort | V. I. Larkin |
| collection | DOAJ |
| description | The aim of the study was to assess the course of epilepsy in patients with signs of cranio-cerebral imbalance with a low CSF-cranial index.Materials and methods. We conducted a prospective analysis of clinical, instrumental and laboratory data from the case histories of 78 patients with epileptic seizures (cryptogenic epilepsy). Group I included 36 patients with normal reserve CSF volumes and physiological values of the CSF-cranial index; these patients received standard multicomponent therapy. Group II was comprised of 42 patients with abnormally small reserve CSF spaces and a lower than normal CSF-cranial index; patients in group II received the same treatment as did patients in group I.Results. We found a moderate correlation between the head circumference and the values of the CSF-cranial index. A strong correlation between the seizure occurrence rate and the values of the CSF-cranial index was also found (R=0.32, p=0.0043); the seizure rate correlation with the head circumference was less obvious (R=0.11, p=0.037). Most of the patients in group I had bilateral seizures, whereas in patients of group II the seizures were of a mixed character.Conclusion. The results of this clinical study suggest that the course of epilepsy in patients with a low CSF-cranial index is determined by the severity of anatomical reduction in the CSF dynamics; in most cases of a low CSF-cranial index, the course of epilepsy is severe. These findings should be considered at the starting and the later stages of antiepileptic therapy. |
| format | Article |
| id | doaj-art-c1d49fffeea645e68e49a9e8fc246664 |
| institution | Kabale University |
| issn | 2077-8333 2311-4088 |
| language | Russian |
| publishDate | 2018-11-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Эпилепсия и пароксизмальные состояния |
| spelling | doaj-art-c1d49fffeea645e68e49a9e8fc2466642025-08-20T03:57:32ZrusIRBIS LLCЭпилепсия и пароксизмальные состояния2077-83332311-40882018-11-01103384310.17749/2077-8333.2018.10.3.038-043408Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial indexV. I. Larkin0N. S. Stelmakh1Omsk State Medical UniversityOmsk State Medical UniversityThe aim of the study was to assess the course of epilepsy in patients with signs of cranio-cerebral imbalance with a low CSF-cranial index.Materials and methods. We conducted a prospective analysis of clinical, instrumental and laboratory data from the case histories of 78 patients with epileptic seizures (cryptogenic epilepsy). Group I included 36 patients with normal reserve CSF volumes and physiological values of the CSF-cranial index; these patients received standard multicomponent therapy. Group II was comprised of 42 patients with abnormally small reserve CSF spaces and a lower than normal CSF-cranial index; patients in group II received the same treatment as did patients in group I.Results. We found a moderate correlation between the head circumference and the values of the CSF-cranial index. A strong correlation between the seizure occurrence rate and the values of the CSF-cranial index was also found (R=0.32, p=0.0043); the seizure rate correlation with the head circumference was less obvious (R=0.11, p=0.037). Most of the patients in group I had bilateral seizures, whereas in patients of group II the seizures were of a mixed character.Conclusion. The results of this clinical study suggest that the course of epilepsy in patients with a low CSF-cranial index is determined by the severity of anatomical reduction in the CSF dynamics; in most cases of a low CSF-cranial index, the course of epilepsy is severe. These findings should be considered at the starting and the later stages of antiepileptic therapy.https://www.epilepsia.su/jour/article/view/425epilepsycranio-cerebral imbalancecsf-cranial index |
| spellingShingle | V. I. Larkin N. S. Stelmakh Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index Эпилепсия и пароксизмальные состояния epilepsy cranio-cerebral imbalance csf-cranial index |
| title | Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index |
| title_full | Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index |
| title_fullStr | Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index |
| title_full_unstemmed | Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index |
| title_short | Course of epilepsy in patients with clinical manifestations of cranio-cerebral imbalance and a low scf-cranial index |
| title_sort | course of epilepsy in patients with clinical manifestations of cranio cerebral imbalance and a low scf cranial index |
| topic | epilepsy cranio-cerebral imbalance csf-cranial index |
| url | https://www.epilepsia.su/jour/article/view/425 |
| work_keys_str_mv | AT vilarkin courseofepilepsyinpatientswithclinicalmanifestationsofcraniocerebralimbalanceandalowscfcranialindex AT nsstelmakh courseofepilepsyinpatientswithclinicalmanifestationsofcraniocerebralimbalanceandalowscfcranialindex |