Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease
A rare case of Castleman's disease presenting as Crohn's disease is described. This 21-year-old male with chronic neutropenia for one year presented with recurrent right lower quadrant pain of two years' duration. Small bowel follow-through suggested Crohn's of the terminal ileum...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1998-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1998/428050 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549885083123712 |
|---|---|
| author | Kelly W Burak Ronald J Bridges Walter B Blahey |
| author_facet | Kelly W Burak Ronald J Bridges Walter B Blahey |
| author_sort | Kelly W Burak |
| collection | DOAJ |
| description | A rare case of Castleman's disease presenting as Crohn's disease is described. This 21-year-old male with chronic neutropenia for one year presented with recurrent right lower quadrant pain of two years' duration. Small bowel follow-through suggested Crohn's of the terminal ileum. Colonoscopy confirmed ulcerations in the terminal ileum and cecum, with biopsies showing necrosis and inflammation. Treatment was initiated with prednisone, 5-aminosalicylate and granulocyte colony-stimulating factor for neutropenia. Symptoms recurred one year later, and repeat colonoscopy showed a focal cecal ulceration. Two years after presentation a resection was planned. Laparotomy revealed a normal ileocecal region and a large retroperitoneal mass of lymphadenopathy. Biopsies confirmed reactive hyperplasia, consistent with the plasma cell variant of Castleman's disease. Chemotherapy has resulted in improvement of symptoms and decrease in mass size, but cecal ulceration persisted. This case illustrates a variant presentation of Castleman's disease with neutropenia and manifestations in the gastrointestinal tract. |
| format | Article |
| id | doaj-art-c1c538d52a6b42098698131d3aa4bbce |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1998-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-c1c538d52a6b42098698131d3aa4bbce2025-02-03T06:08:21ZengWileyCanadian Journal of Gastroenterology0835-79001998-01-0112427027210.1155/1998/428050Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s DiseaseKelly W Burak0Ronald J Bridges1Walter B Blahey2Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Medicine, University of Calgary, Calgary, Alberta, CanadaA rare case of Castleman's disease presenting as Crohn's disease is described. This 21-year-old male with chronic neutropenia for one year presented with recurrent right lower quadrant pain of two years' duration. Small bowel follow-through suggested Crohn's of the terminal ileum. Colonoscopy confirmed ulcerations in the terminal ileum and cecum, with biopsies showing necrosis and inflammation. Treatment was initiated with prednisone, 5-aminosalicylate and granulocyte colony-stimulating factor for neutropenia. Symptoms recurred one year later, and repeat colonoscopy showed a focal cecal ulceration. Two years after presentation a resection was planned. Laparotomy revealed a normal ileocecal region and a large retroperitoneal mass of lymphadenopathy. Biopsies confirmed reactive hyperplasia, consistent with the plasma cell variant of Castleman's disease. Chemotherapy has resulted in improvement of symptoms and decrease in mass size, but cecal ulceration persisted. This case illustrates a variant presentation of Castleman's disease with neutropenia and manifestations in the gastrointestinal tract.http://dx.doi.org/10.1155/1998/428050 |
| spellingShingle | Kelly W Burak Ronald J Bridges Walter B Blahey Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease |
| title_full | Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease |
| title_fullStr | Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease |
| title_full_unstemmed | Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease |
| title_short | Castleman's Disease and Neutropenic Enterocolitis Presenting as Crohn’s Disease |
| title_sort | castleman s disease and neutropenic enterocolitis presenting as crohn s disease |
| url | http://dx.doi.org/10.1155/1998/428050 |
| work_keys_str_mv | AT kellywburak castlemansdiseaseandneutropenicenterocolitispresentingascrohnsdisease AT ronaldjbridges castlemansdiseaseandneutropenicenterocolitispresentingascrohnsdisease AT walterbblahey castlemansdiseaseandneutropenicenterocolitispresentingascrohnsdisease |