Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy
Objective. To examine the changes in retinal thickness of patients with diabetes without DR. Designs. A randomization, crossover, retrospective practice. Participants. 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. Methods. Full retinal thicknesses of ten areas were assessed us...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2018/3082893 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566854092062720 |
|---|---|
| author | Jing Jiang Yan Liu Yingchao Chen Bo Ma Yiwen Qian Zhenzhen Zhang Dongqing Zhu Zhiliang Wang Xiaofang Xu |
| author_facet | Jing Jiang Yan Liu Yingchao Chen Bo Ma Yiwen Qian Zhenzhen Zhang Dongqing Zhu Zhiliang Wang Xiaofang Xu |
| author_sort | Jing Jiang |
| collection | DOAJ |
| description | Objective. To examine the changes in retinal thickness of patients with diabetes without DR. Designs. A randomization, crossover, retrospective practice. Participants. 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. Methods. Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis. Main Outcome Measures. Mean retinal thickness of ten areas. Results. The mean thickness of the fovea was 215.8 ± 18.9 μm in the diabetes group and 222.0 ± 18.6 μm in the control group (p=0.04). The mean thickness of the temporal parafovea was 319.9 ± 16.7 μm in the diabetes group and 326.0 ± 14.4 μm in the control group (p=0.01). The mean thickness of the temporal perifovea was 276.4 ± 27.9 μm in the diabetes group and 284.8 ± 17.4 μm in the control group (p=0.02). There were no significant differences in retinal thickness between groups in other areas (p>0.05). Regression analysis revealed that decreased retinal thickness of the temporal perifovea was associated with a higher HbA1c level (>8.7%) (p=0.04). Conclusion and Relevance. Subtle structural changes in the retina may occur in diabetes without DR. Decreased retinal thickness appeared to begin in the fovea and temporal areas. A high HbA1c level was the main factor influencing retinal thickness. |
| format | Article |
| id | doaj-art-c1be074a75ce4cf29eee163596fdf0e2 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-c1be074a75ce4cf29eee163596fdf0e22025-02-03T01:03:01ZengWileyJournal of Diabetes Research2314-67452314-67532018-01-01201810.1155/2018/30828933082893Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic RetinopathyJing Jiang0Yan Liu1Yingchao Chen2Bo Ma3Yiwen Qian4Zhenzhen Zhang5Dongqing Zhu6Zhiliang Wang7Xiaofang Xu8Department of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Endocrinology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital of Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, ChinaObjective. To examine the changes in retinal thickness of patients with diabetes without DR. Designs. A randomization, crossover, retrospective practice. Participants. 43 diabetic patients and 43 ethnic-, age-, and sex-matched controls. Methods. Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis. Main Outcome Measures. Mean retinal thickness of ten areas. Results. The mean thickness of the fovea was 215.8 ± 18.9 μm in the diabetes group and 222.0 ± 18.6 μm in the control group (p=0.04). The mean thickness of the temporal parafovea was 319.9 ± 16.7 μm in the diabetes group and 326.0 ± 14.4 μm in the control group (p=0.01). The mean thickness of the temporal perifovea was 276.4 ± 27.9 μm in the diabetes group and 284.8 ± 17.4 μm in the control group (p=0.02). There were no significant differences in retinal thickness between groups in other areas (p>0.05). Regression analysis revealed that decreased retinal thickness of the temporal perifovea was associated with a higher HbA1c level (>8.7%) (p=0.04). Conclusion and Relevance. Subtle structural changes in the retina may occur in diabetes without DR. Decreased retinal thickness appeared to begin in the fovea and temporal areas. A high HbA1c level was the main factor influencing retinal thickness.http://dx.doi.org/10.1155/2018/3082893 |
| spellingShingle | Jing Jiang Yan Liu Yingchao Chen Bo Ma Yiwen Qian Zhenzhen Zhang Dongqing Zhu Zhiliang Wang Xiaofang Xu Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy Journal of Diabetes Research |
| title | Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy |
| title_full | Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy |
| title_fullStr | Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy |
| title_full_unstemmed | Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy |
| title_short | Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy |
| title_sort | analysis of changes in retinal thickness in type 2 diabetes without diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2018/3082893 |
| work_keys_str_mv | AT jingjiang analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT yanliu analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT yingchaochen analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT boma analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT yiwenqian analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT zhenzhenzhang analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT dongqingzhu analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT zhiliangwang analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy AT xiaofangxu analysisofchangesinretinalthicknessintype2diabeteswithoutdiabeticretinopathy |