Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy
In cancer biology, cells and molecules that form the fundamental components of the tumor microenvironment play a major role in tumor initiation, and progression as well as responses to therapy. Therapeutic approaches that would enable and harness the immune system to target tumor cells mark the futu...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/308574 |
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| _version_ | 1850176500614037504 |
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| author | Vinod Vijay Subhash Mei Shi Yeo Woei Loon Tan Wei Peng Yong |
| author_facet | Vinod Vijay Subhash Mei Shi Yeo Woei Loon Tan Wei Peng Yong |
| author_sort | Vinod Vijay Subhash |
| collection | DOAJ |
| description | In cancer biology, cells and molecules that form the fundamental components of the tumor microenvironment play a major role in tumor initiation, and progression as well as responses to therapy. Therapeutic approaches that would enable and harness the immune system to target tumor cells mark the future of anticancer therapy as it could induce an immunological memory specific to the tumor type and further enhance tumor regression and relapse-free survival in cancer patients. Gastric cancer is one of the leading causes of cancer-related mortalities that has a modest survival benefit from existing treatment options. The advent of immunotherapy presents us with new approaches in gastric cancer treatment where adaptive cell therapies, cancer vaccines, and antibody therapies have all been used with promising outcomes. In this paper, we review the current advances and prospects in the gastric cancer immunotherapy. Special focus is laid on new strategies and clinical trials that attempt to enhance the efficacy of various immunotherapeutic modalities in gastric cancer. |
| format | Article |
| id | doaj-art-c1bdd64a31de494380a741c91d7f6ab9 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-c1bdd64a31de494380a741c91d7f6ab92025-08-20T02:19:15ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/308574308574Strategies and Advancements in Harnessing the Immune System for Gastric Cancer ImmunotherapyVinod Vijay Subhash0Mei Shi Yeo1Woei Loon Tan2Wei Peng Yong3Cancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, 119228, SingaporeDepartment of Haematology-Oncology, National University Hospital, 119228, SingaporeDepartment of Haematology-Oncology, National University Hospital, 119228, SingaporeCancer Science Institute of Singapore, Yong Loo Lin School of Medicine, National University of Singapore, 119228, SingaporeIn cancer biology, cells and molecules that form the fundamental components of the tumor microenvironment play a major role in tumor initiation, and progression as well as responses to therapy. Therapeutic approaches that would enable and harness the immune system to target tumor cells mark the future of anticancer therapy as it could induce an immunological memory specific to the tumor type and further enhance tumor regression and relapse-free survival in cancer patients. Gastric cancer is one of the leading causes of cancer-related mortalities that has a modest survival benefit from existing treatment options. The advent of immunotherapy presents us with new approaches in gastric cancer treatment where adaptive cell therapies, cancer vaccines, and antibody therapies have all been used with promising outcomes. In this paper, we review the current advances and prospects in the gastric cancer immunotherapy. Special focus is laid on new strategies and clinical trials that attempt to enhance the efficacy of various immunotherapeutic modalities in gastric cancer.http://dx.doi.org/10.1155/2015/308574 |
| spellingShingle | Vinod Vijay Subhash Mei Shi Yeo Woei Loon Tan Wei Peng Yong Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy Journal of Immunology Research |
| title | Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy |
| title_full | Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy |
| title_fullStr | Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy |
| title_full_unstemmed | Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy |
| title_short | Strategies and Advancements in Harnessing the Immune System for Gastric Cancer Immunotherapy |
| title_sort | strategies and advancements in harnessing the immune system for gastric cancer immunotherapy |
| url | http://dx.doi.org/10.1155/2015/308574 |
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