Generation and characterisation of seven induced pluripotent stem cell lines from two patients with Parkinson’s disease carrying the pathological variant c.1087G>T of the <i>LGR4</i> gene

Generation and characterisation of seven induced pluripotent stem cell lines from two patients with Parkinson’s disease carrying the pathological variant c.1087G>T of the <i>LGR4</i> gene

Parkinson’s disease is a neurodegenerative disorder affecting dopaminergic neurons of the substantia nigra pars compacta. The known pathological genetic variants may explain the cause of only 5 % of cases of the disease. In our study, we found two patients with a clinical diagnosis of Parkinson’s di...

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Main Authors: V. S. Podvysotskaya, E. V. Grigor’eva, A. A. Malakhova, J. M. Minina, Y. V. Vyatkin, E. A. Khabarova, J. A. Rzaev, S. P. Medvedev, L. V. Kovalenko, S. M. Zakian
Format: Article
Language:English
Published: Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders 2025-03-01
Series:Вавиловский журнал генетики и селекции
Subjects:
parkinson’s disease
reprogramming
induced pluripotent stem cells
<i>lgr4</i> gene
Online Access:https://vavilov.elpub.ru/jour/article/view/4469
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