Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy
Heat shock proteins belong to a highly conserved family of chaperone proteins, and in addition to their participation in the regulation of cellular proteostasis (folding of polypeptides and proteins, disaggregation of incorrectly folded peptides, and participation in autophagy processes), also play...
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2025-06-01
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| author | Elena Mikhailova Alexandra Sokolenko Stephanie E. Combs Maxim Shevtsov |
| author_facet | Elena Mikhailova Alexandra Sokolenko Stephanie E. Combs Maxim Shevtsov |
| author_sort | Elena Mikhailova |
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| description | Heat shock proteins belong to a highly conserved family of chaperone proteins, and in addition to their participation in the regulation of cellular proteostasis (folding of polypeptides and proteins, disaggregation of incorrectly folded peptides, and participation in autophagy processes), also play a significant immunomodulatory role in both innate and adaptive immunity. Changes in the HSP level, both downwards (e.g., in neurodegenerative diseases) and upwards (e.g., autoimmune, oncological diseases), underlie the pathogenesis of many somatic and oncological pathologies. In this review, we consider the main physiological mechanisms of HSP level regulation and also analyze pharmacological, genetically engineered methods of modulating the chaperone level, citing the advantages and disadvantages of a particular method of influence. In conclusion, modulation of the HSP level, according to numerous preclinical studies, can have a significant impact on the course of various pathological conditions, which, in turn, can be used to develop new therapeutic approaches, when the effect on the level of chaperones can be used as monotherapy or as an adjuvant method of action. |
| format | Article |
| id | doaj-art-c1baae09b98e46008e59f33d94bbe0bd |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Cells |
| spelling | doaj-art-c1baae09b98e46008e59f33d94bbe0bd2025-08-20T03:50:17ZengMDPI AGCells2073-44092025-06-01141397910.3390/cells14130979Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and TherapyElena Mikhailova0Alexandra Sokolenko1Stephanie E. Combs2Maxim Shevtsov3Personalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, RussiaDepartment of Molecular Biotechnology, Saint-Petersburg State Institute of Technology, 190013 Saint Petersburg, RussiaDepartment of Radiation Oncology, Technishe Universität München (TUM), Klinikum Rechts der Isar, Ismaninger Str. 22, 81675 Munich, GermanyPersonalized Medicine Centre, Almazov National Medical Research Centre, 2 Akkuratova Str., 197341 Saint Petersburg, RussiaHeat shock proteins belong to a highly conserved family of chaperone proteins, and in addition to their participation in the regulation of cellular proteostasis (folding of polypeptides and proteins, disaggregation of incorrectly folded peptides, and participation in autophagy processes), also play a significant immunomodulatory role in both innate and adaptive immunity. Changes in the HSP level, both downwards (e.g., in neurodegenerative diseases) and upwards (e.g., autoimmune, oncological diseases), underlie the pathogenesis of many somatic and oncological pathologies. In this review, we consider the main physiological mechanisms of HSP level regulation and also analyze pharmacological, genetically engineered methods of modulating the chaperone level, citing the advantages and disadvantages of a particular method of influence. In conclusion, modulation of the HSP level, according to numerous preclinical studies, can have a significant impact on the course of various pathological conditions, which, in turn, can be used to develop new therapeutic approaches, when the effect on the level of chaperones can be used as monotherapy or as an adjuvant method of action.https://www.mdpi.com/2073-4409/14/13/979heat shock proteinschaperonesHSP70HSP90HSFbiomarker |
| spellingShingle | Elena Mikhailova Alexandra Sokolenko Stephanie E. Combs Maxim Shevtsov Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy Cells heat shock proteins chaperones HSP70 HSP90 HSF biomarker |
| title | Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy |
| title_full | Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy |
| title_fullStr | Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy |
| title_full_unstemmed | Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy |
| title_short | Modulation of Heat Shock Proteins Levels in Health and Disease: An Integrated Perspective in Diagnostics and Therapy |
| title_sort | modulation of heat shock proteins levels in health and disease an integrated perspective in diagnostics and therapy |
| topic | heat shock proteins chaperones HSP70 HSP90 HSF biomarker |
| url | https://www.mdpi.com/2073-4409/14/13/979 |
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