Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Abstract Hypertension remains a leading cause of cardiovascular and kidney diseases. Failure to control blood pressure with ≥ 3 medications or control requiring ≥ 4 medications is classified as resistant hypertension (rHTN) and new therapies are needed to reduce the resulting increased risk of morbi...

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Main Authors: Shan-Shan Zhang, Lance Larrabee, Andrew H. Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C. Hartman, Abby Whitnall, Joseph Mason, Nicholas P. Barton, Audrey Y. Chu, Jonathan M. Davitte, Adam J. Csakai, Caitlin Vestal Tibbetts, Audrey E. Tolbert, Heather O’Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P. Mayer, Patrick Koenig, Davide Foletti, Steven J. Pitts, Christine G. Schnackenberg
Format: Article
Language:English
Published: Nature Portfolio 2024-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-62804-7
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