The role of neurofilament light chain in the context of neurological disorders
Neurofilament light chain (NFL) is a structural neuronal protein highly expressed in large myelinated axons. Axonal damage leads to increased NFL levels in cerebrospinal fluid and blood. Therefore, it could be a potential diagnostic biomarker for various neurological disorders, especially caused by...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2020-12-01
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| Series: | Neurologijos seminarai |
| Subjects: | |
| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27707 |
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| _version_ | 1832593085741137920 |
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| author | V. Taluntienė R. Motiekaitytė R. Kizlaitienė N. Giedraitienė G. Kaubrys |
| author_facet | V. Taluntienė R. Motiekaitytė R. Kizlaitienė N. Giedraitienė G. Kaubrys |
| author_sort | V. Taluntienė |
| collection | DOAJ |
| description |
Neurofilament light chain (NFL) is a structural neuronal protein highly expressed in large myelinated axons. Axonal damage leads to increased NFL levels in cerebrospinal fluid and blood. Therefore, it could be a potential diagnostic biomarker for various neurological disorders, especially caused by neurodegeneration and inflammation. New sensitive immunoassays for NFL measurement in the blood offer possibilities of monitoring disease progression and assessing treatment response. An increasing amount of data suggests that NFL could also be a prognostic marker for many disorders. The purpose of this article is to review the literature on the role of NFL in the context of dementia, amyotrophic lateral sclerosis, HIV-associated neurocognitive disorders, multiple sclerosis, and other neurological diseases.
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| format | Article |
| id | doaj-art-c1b58087aaf44a23b5fd1b5abf3ed160 |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2020-12-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-c1b58087aaf44a23b5fd1b5abf3ed1602025-01-20T18:22:36ZengVilnius University PressNeurologijos seminarai1392-30642424-59172020-12-01244(86)10.29014/ns.2020.37The role of neurofilament light chain in the context of neurological disordersV. Taluntienė 0R. Motiekaitytė 1R. Kizlaitienė 2N. Giedraitienė 3G. Kaubrys 4Vilnius University, LithuaniaVilnius University, LithuaniaVilnius University, LithuaniaVilnius University, LithuaniaVilnius University, Lithuania Neurofilament light chain (NFL) is a structural neuronal protein highly expressed in large myelinated axons. Axonal damage leads to increased NFL levels in cerebrospinal fluid and blood. Therefore, it could be a potential diagnostic biomarker for various neurological disorders, especially caused by neurodegeneration and inflammation. New sensitive immunoassays for NFL measurement in the blood offer possibilities of monitoring disease progression and assessing treatment response. An increasing amount of data suggests that NFL could also be a prognostic marker for many disorders. The purpose of this article is to review the literature on the role of NFL in the context of dementia, amyotrophic lateral sclerosis, HIV-associated neurocognitive disorders, multiple sclerosis, and other neurological diseases. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27707neurofilament light chainaxonal damageneurodegenerationmultiple sclerosis |
| spellingShingle | V. Taluntienė R. Motiekaitytė R. Kizlaitienė N. Giedraitienė G. Kaubrys The role of neurofilament light chain in the context of neurological disorders Neurologijos seminarai neurofilament light chain axonal damage neurodegeneration multiple sclerosis |
| title | The role of neurofilament light chain in the context of neurological disorders |
| title_full | The role of neurofilament light chain in the context of neurological disorders |
| title_fullStr | The role of neurofilament light chain in the context of neurological disorders |
| title_full_unstemmed | The role of neurofilament light chain in the context of neurological disorders |
| title_short | The role of neurofilament light chain in the context of neurological disorders |
| title_sort | role of neurofilament light chain in the context of neurological disorders |
| topic | neurofilament light chain axonal damage neurodegeneration multiple sclerosis |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27707 |
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