Stem Cell Perspective for Regenerative Wound Healing: from Biology toward Future Clinical Directions: A Review
Chronic wounds, a major clinical challenge, still need to develop new methods based on efficient technologies to improvetreatment results. Stem cells, particularly mesenchymal stem cells (MSC), as an advanced approach in skin regenerativemedicine, brought new hopes. The multifaceted effects of MSCs,...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Royan Institute (ACECR), Tehran
2024-10-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | https://www.celljournal.org/article_719396_d41d8cd98f00b204e9800998ecf8427e.pdf |
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| Summary: | Chronic wounds, a major clinical challenge, still need to develop new methods based on efficient technologies to improvetreatment results. Stem cells, particularly mesenchymal stem cells (MSC), as an advanced approach in skin regenerativemedicine, brought new hopes. The multifaceted effects of MSCs, including paracrine signaling, trophic factor secretion, andmodulation of the wound microenvironment, orchestrate a cascade of regenerative, plays a critical role in tissue repair. Preclinicalinvestigations have revealed the regenerative capacity of MSCs in accelerating wound closure, promoting angiogenesis, andfostering a pro-healing environment in chronic wound models. Clinical trials have also confirmed these findings and show theefficacy of MSC treatment in accelerating wound healing and improving the quality of healed tissue in patients with chronicwounds. Despite the therapeutic progress, key issues, such as optimal cell sourcing, cell dosage, delivery modalities, andlong-term safety profiles, there are a number of unresolved issues which need to be dealt with. This review aims to provide acomprehensive overview of current state of stem cell research in wound healing, and offers a new new hope for effective andinnovative treatments in regenerative medicine. |
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| ISSN: | 2228-5806 2228-5814 |