Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis
Objectives: This retrospective study was conducted to elucidate the impact of intraoperative redosing of antibiotics (IRA) on the incidence of surgical site infection (SSI) in elective colorectal surgery. Methods: The study involved 61 patient pairs matched 1:1 from among 200 patients who, between A...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Coloproctology
2025-04-01
|
| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/2/9_2024-101/_pdf/-char/en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850138903282974720 |
|---|---|
| author | Yozo Suzuki Masakazu Ikenaga Kiyotaka Hagihara Toshiki Noma Katsunori Matsushita Naoki Shinno Masafumi Yamashita Yoshitomo Yanagimoto Mitsuyoshi Tei Junzo Shimizu Naohiro Tomita Hiroshi Imamura |
| author_facet | Yozo Suzuki Masakazu Ikenaga Kiyotaka Hagihara Toshiki Noma Katsunori Matsushita Naoki Shinno Masafumi Yamashita Yoshitomo Yanagimoto Mitsuyoshi Tei Junzo Shimizu Naohiro Tomita Hiroshi Imamura |
| author_sort | Yozo Suzuki |
| collection | DOAJ |
| description | Objectives: This retrospective study was conducted to elucidate the impact of intraoperative redosing of antibiotics (IRA) on the incidence of surgical site infection (SSI) in elective colorectal surgery.
Methods: The study involved 61 patient pairs matched 1:1 from among 200 patients who, between April 2019 and December 2020, underwent elective surgery of 180 minutes or longer for colorectal cancer either with or without IRA at our hospital. The incidence of SSI, length of stay after surgery, readmission rate, and reoperation rate were compared between the two groups.
Results: No significant between-group difference was found in patient or tumor characteristics or in operative factors. Further, no significant between-group difference was found in the incidence of SSI (with IRA vs. without IRA: 4.9% vs. 4.9%, p=1.000), length of stay after surgery (median 15 [IQR 11-21] days vs. 13 [10-23] days; p=0.302), or reoperation rate (3.3% vs. 0%, p=0.154). No patients in either group were readmitted.
Conclusions: The incidence of SSI, length of stay after surgery, and reoperation rate of the without IRA group were comparable to those of the with IRA group in elective surgery of 180 minutes or longer for colorectal cancer. |
| format | Article |
| id | doaj-art-c1aec973fdc741e2b513901bbcb1bba4 |
| institution | OA Journals |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-c1aec973fdc741e2b513901bbcb1bba42025-08-20T02:30:28ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-04-019223724310.23922/jarc.2024-1012024-101Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based AnalysisYozo Suzuki0Masakazu Ikenaga1Kiyotaka Hagihara2Toshiki Noma3Katsunori Matsushita4Naoki Shinno5Masafumi Yamashita6Yoshitomo Yanagimoto7Mitsuyoshi Tei8Junzo Shimizu9Naohiro Tomita10Hiroshi Imamura11Department of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Osaka International Cancer InstituteDepartment of Gastroenterological Surgery, Osaka Rosai HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalDepartment of Gastroenterological Surgery, Toyonaka Municipal HospitalObjectives: This retrospective study was conducted to elucidate the impact of intraoperative redosing of antibiotics (IRA) on the incidence of surgical site infection (SSI) in elective colorectal surgery. Methods: The study involved 61 patient pairs matched 1:1 from among 200 patients who, between April 2019 and December 2020, underwent elective surgery of 180 minutes or longer for colorectal cancer either with or without IRA at our hospital. The incidence of SSI, length of stay after surgery, readmission rate, and reoperation rate were compared between the two groups. Results: No significant between-group difference was found in patient or tumor characteristics or in operative factors. Further, no significant between-group difference was found in the incidence of SSI (with IRA vs. without IRA: 4.9% vs. 4.9%, p=1.000), length of stay after surgery (median 15 [IQR 11-21] days vs. 13 [10-23] days; p=0.302), or reoperation rate (3.3% vs. 0%, p=0.154). No patients in either group were readmitted. Conclusions: The incidence of SSI, length of stay after surgery, and reoperation rate of the without IRA group were comparable to those of the with IRA group in elective surgery of 180 minutes or longer for colorectal cancer.https://www.jstage.jst.go.jp/article/jarc/9/2/9_2024-101/_pdf/-char/enantimicrobial prophylaxisredosingcolorectal surgerysurgical site infection |
| spellingShingle | Yozo Suzuki Masakazu Ikenaga Kiyotaka Hagihara Toshiki Noma Katsunori Matsushita Naoki Shinno Masafumi Yamashita Yoshitomo Yanagimoto Mitsuyoshi Tei Junzo Shimizu Naohiro Tomita Hiroshi Imamura Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis Journal of the Anus, Rectum and Colon antimicrobial prophylaxis redosing colorectal surgery surgical site infection |
| title | Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis |
| title_full | Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis |
| title_fullStr | Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis |
| title_full_unstemmed | Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis |
| title_short | Impact of Prophylactic Intraoperative Redosing of Antibiotics on the Incidence of Surgical Site Infection in Elective Colorectal Surgery: Results of a Propensity Score-based Analysis |
| title_sort | impact of prophylactic intraoperative redosing of antibiotics on the incidence of surgical site infection in elective colorectal surgery results of a propensity score based analysis |
| topic | antimicrobial prophylaxis redosing colorectal surgery surgical site infection |
| url | https://www.jstage.jst.go.jp/article/jarc/9/2/9_2024-101/_pdf/-char/en |
| work_keys_str_mv | AT yozosuzuki impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT masakazuikenaga impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT kiyotakahagihara impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT toshikinoma impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT katsunorimatsushita impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT naokishinno impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT masafumiyamashita impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT yoshitomoyanagimoto impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT mitsuyoshitei impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT junzoshimizu impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT naohirotomita impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis AT hiroshiimamura impactofprophylacticintraoperativeredosingofantibioticsontheincidenceofsurgicalsiteinfectioninelectivecolorectalsurgeryresultsofapropensityscorebasedanalysis |