The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives
This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, an...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-2011-0350 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849684313821413376 |
|---|---|
| author | David Huepe Rodrigo Riveros Facundo Manes Blas Couto Esteban Hurtado Marcelo Cetkovich Maria Escobar Viviana Vergara Teresa Parrao Agustin Ibañez |
| author_facet | David Huepe Rodrigo Riveros Facundo Manes Blas Couto Esteban Hurtado Marcelo Cetkovich Maria Escobar Viviana Vergara Teresa Parrao Agustin Ibañez |
| author_sort | David Huepe |
| collection | DOAJ |
| description | This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability. |
| format | Article |
| id | doaj-art-c1aec8ea78224b6b963f080fabb10d26 |
| institution | DOAJ |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-c1aec8ea78224b6b963f080fabb10d262025-08-20T03:23:30ZengWileyBehavioural Neurology0953-41801875-85842012-01-0125213715010.3233/BEN-2011-0350The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and RelativesDavid Huepe0Rodrigo Riveros1Facundo Manes2Blas Couto3Esteban Hurtado4Marcelo Cetkovich5Maria Escobar6Viviana Vergara7Teresa Parrao8Agustin Ibañez9Laboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChilePontificia Universidad Católica de Chile, Santiago, ChileLaboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology (INECO) and Institute of Neuroscience, Favaloro University, Buenos Aires, ArgentinaLaboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology (INECO) and Institute of Neuroscience, Favaloro University, Buenos Aires, ArgentinaLaboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChileLaboratory of Experimental Psychology and Neuroscience, Institute of Cognitive Neurology (INECO) and Institute of Neuroscience, Favaloro University, Buenos Aires, ArgentinaLaboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChileLaboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChileLaboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChileLaboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, ChileThis study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tesks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.http://dx.doi.org/10.3233/BEN-2011-0350 |
| spellingShingle | David Huepe Rodrigo Riveros Facundo Manes Blas Couto Esteban Hurtado Marcelo Cetkovich Maria Escobar Viviana Vergara Teresa Parrao Agustin Ibañez The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives Behavioural Neurology |
| title | The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives |
| title_full | The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives |
| title_fullStr | The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives |
| title_full_unstemmed | The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives |
| title_short | The Relationship of Clinical, Cognitive and Social Measures in Schizophrenia: A Preliminary Finding Combining Measures in Probands and Relatives |
| title_sort | relationship of clinical cognitive and social measures in schizophrenia a preliminary finding combining measures in probands and relatives |
| url | http://dx.doi.org/10.3233/BEN-2011-0350 |
| work_keys_str_mv | AT davidhuepe therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT rodrigoriveros therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT facundomanes therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT blascouto therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT estebanhurtado therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT marcelocetkovich therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT mariaescobar therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT vivianavergara therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT teresaparrao therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT agustinibanez therelationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT davidhuepe relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT rodrigoriveros relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT facundomanes relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT blascouto relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT estebanhurtado relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT marcelocetkovich relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT mariaescobar relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT vivianavergara relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT teresaparrao relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives AT agustinibanez relationshipofclinicalcognitiveandsocialmeasuresinschizophreniaapreliminaryfindingcombiningmeasuresinprobandsandrelatives |