The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis
IntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited efficacy in certain patients and are associated with adverse effects, which highlights the need for safer and more effe...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| author | Femke Van Gaever Femke Van Gaever Fleur Mingneau Fleur Mingneau Sam Vanherle Sam Vanherle Yasmine Driege Yasmine Driege Mira Haegman Mira Haegman Elien Van Wonterghem Elien Van Wonterghem Junhua Xie Junhua Xie Roosmarijn E. Vandenbroucke Roosmarijn E. Vandenbroucke Jerome J. A. Hendriks Jerome J. A. Hendriks Rudi Beyaert Rudi Beyaert Jens Staal Jens Staal Jens Staal |
| author_facet | Femke Van Gaever Femke Van Gaever Fleur Mingneau Fleur Mingneau Sam Vanherle Sam Vanherle Yasmine Driege Yasmine Driege Mira Haegman Mira Haegman Elien Van Wonterghem Elien Van Wonterghem Junhua Xie Junhua Xie Roosmarijn E. Vandenbroucke Roosmarijn E. Vandenbroucke Jerome J. A. Hendriks Jerome J. A. Hendriks Rudi Beyaert Rudi Beyaert Jens Staal Jens Staal Jens Staal |
| author_sort | Femke Van Gaever |
| collection | DOAJ |
| description | IntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited efficacy in certain patients and are associated with adverse effects, which highlights the need for safer and more effective therapeutic approaches. Environmental factors, particularly dietary habits, have been observed to play a substantial role in the development of MS. In this study, we are the first to investigate the potential protective effect of the phytohormone abscisic acid (ABA) in MS. ABA, which is abundant in fruits such as figs, apricots and bilberries, is known to cross the blood-brain barrier and has demonstrated neuroprotective effects in conditions like depression and Alzheimer's disease.MethodsIn this study, we investigated whether ABA supplementation enhances remyelination in both ex vivo and in vivo mouse models.ResultsOur results indicated that ABA enhanced remyelination and that this enhanced remyelination is associated with increased lipid droplet load, reduced levels of degraded myelin, and a higher abundance of F4/80+ cells in the demyelinated brain of mice treated with ABA. In in vitro models, we further demonstrated that ABA treatment elevates lipid droplet formation by enhancing the phagocytic capacity of macrophages. Additionally, in a mouse model of microglial activation, we showed that ABA-treated mice maintain a less inflammatory microglial phenotype.ConclusionOur findings highlight a crucial role for macrophages and microglia in enabling ABA to enhance the remyelination process. Furthermore, ABA’s ability to improve remyelination together with its ability to reduce microglial activation, make ABA a promising candidate for modulating macrophage phenotype and reducing neuroinflammation in MS. |
| format | Article |
| id | doaj-art-c1abff27166741e5a0987d513d85e488 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj-art-c1abff27166741e5a0987d513d85e4882025-02-07T09:25:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.15006971500697The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosisFemke Van Gaever0Femke Van Gaever1Fleur Mingneau2Fleur Mingneau3Sam Vanherle4Sam Vanherle5Yasmine Driege6Yasmine Driege7Mira Haegman8Mira Haegman9Elien Van Wonterghem10Elien Van Wonterghem11Junhua Xie12Junhua Xie13Roosmarijn E. Vandenbroucke14Roosmarijn E. Vandenbroucke15Jerome J. A. Hendriks16Jerome J. A. Hendriks17Rudi Beyaert18Rudi Beyaert19Jens Staal20Jens Staal21Jens Staal22VIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, BelgiumUniversity MS Center Hasselt, Pelt, BelgiumDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, BelgiumUniversity MS Center Hasselt, Pelt, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumDepartment of Immunology and Infection, Biomedical Research Institute, Hasselt University, Diepenbeek, BelgiumUniversity MS Center Hasselt, Pelt, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumVIB-UGent Center for Inflammation Research, VIB, Ghent, BelgiumDepartment of Biomedical Molecular Biology, Ghent University, Ghent, BelgiumDepartment of Biochemistry and Microbiology, Ghent University, Ghent, BelgiumIntroductionOver the past few decades, there has been a sudden rise in the incidence of Multiple Sclerosis (MS) in Western countries. However, current treatments often show limited efficacy in certain patients and are associated with adverse effects, which highlights the need for safer and more effective therapeutic approaches. Environmental factors, particularly dietary habits, have been observed to play a substantial role in the development of MS. In this study, we are the first to investigate the potential protective effect of the phytohormone abscisic acid (ABA) in MS. ABA, which is abundant in fruits such as figs, apricots and bilberries, is known to cross the blood-brain barrier and has demonstrated neuroprotective effects in conditions like depression and Alzheimer's disease.MethodsIn this study, we investigated whether ABA supplementation enhances remyelination in both ex vivo and in vivo mouse models.ResultsOur results indicated that ABA enhanced remyelination and that this enhanced remyelination is associated with increased lipid droplet load, reduced levels of degraded myelin, and a higher abundance of F4/80+ cells in the demyelinated brain of mice treated with ABA. In in vitro models, we further demonstrated that ABA treatment elevates lipid droplet formation by enhancing the phagocytic capacity of macrophages. Additionally, in a mouse model of microglial activation, we showed that ABA-treated mice maintain a less inflammatory microglial phenotype.ConclusionOur findings highlight a crucial role for macrophages and microglia in enabling ABA to enhance the remyelination process. Furthermore, ABA’s ability to improve remyelination together with its ability to reduce microglial activation, make ABA a promising candidate for modulating macrophage phenotype and reducing neuroinflammation in MS.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500697/fullabscisic acidremyelinationmacrophagesmicrogliamultiple sclerosismyelin |
| spellingShingle | Femke Van Gaever Femke Van Gaever Fleur Mingneau Fleur Mingneau Sam Vanherle Sam Vanherle Yasmine Driege Yasmine Driege Mira Haegman Mira Haegman Elien Van Wonterghem Elien Van Wonterghem Junhua Xie Junhua Xie Roosmarijn E. Vandenbroucke Roosmarijn E. Vandenbroucke Jerome J. A. Hendriks Jerome J. A. Hendriks Rudi Beyaert Rudi Beyaert Jens Staal Jens Staal Jens Staal The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis Frontiers in Immunology abscisic acid remyelination macrophages microglia multiple sclerosis myelin |
| title | The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| title_full | The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| title_fullStr | The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| title_full_unstemmed | The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| title_short | The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| title_sort | phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis |
| topic | abscisic acid remyelination macrophages microglia multiple sclerosis myelin |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500697/full |
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