Caspase-1 knockout disrupts pyroptosis and protects photoreceptor cells from photochemical damage

Caspase-1 knockout disrupts pyroptosis and protects photoreceptor cells from photochemical damage

Aim: Retinal photochemical damage (RPD) plays a significant role in the development of various ocular diseases, with Caspase-1 being a key contributor. This study investigates the protective effects of Caspase-1 gene-mediated pyroptosis against RPD. Methods: Differentially expressed genes (DEGs) ass...

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Bibliographic Details
Main Authors: Xiaoping Yu, Jiayuan Peng, Qian Zhong, Ailin Wu, Xiaoming Deng, Yanfeng Zhu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Molecular and Cellular Probes
Subjects:
CRISPR/Cas9 System
Caspase-1 Gene
Gene Knockout
Pyroptosis
Retinal Photochemical Damage
Online Access:http://www.sciencedirect.com/science/article/pii/S0890850824000434
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