Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia
<i>Background and Objectives:</i> This study explores the immunogenetic associations of human leukocyte antigens (HLAs) and cytokine levels in people living with HIV/AIDS (PLWH) who exhibit HIV-related skin disorders. HIV-related skin disorders, including inflammatory eruptions, atopic a...
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2025-06-01
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| author | Alena Soha Inga Azina Maksims Zolovs Darja Arina Miskina Viktorija Murasko Baiba Rozentale Ilona Hartmane Andris Rubins |
| author_facet | Alena Soha Inga Azina Maksims Zolovs Darja Arina Miskina Viktorija Murasko Baiba Rozentale Ilona Hartmane Andris Rubins |
| author_sort | Alena Soha |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> This study explores the immunogenetic associations of human leukocyte antigens (HLAs) and cytokine levels in people living with HIV/AIDS (PLWH) who exhibit HIV-related skin disorders. HIV-related skin disorders, including inflammatory eruptions, atopic and seborrheic dermatitis, psoriasis, and pruritic papular eruption, are common among PLWH. These conditions may be influenced by genetic and immunological factors. This study aims to investigate the associations between HLA class II alleles, cytokine levels, and the presence of HIV-related dermatoses, providing insights into genetic susceptibility and immune mechanisms. <i>Materials and Methods:</i> This study included 115 PLWH with HIV-related skin disorders and a control group of 80 healthy individuals. HLA allele frequencies were analyzed, and cytokine levels (IL-1β, IL-10, IFN-y) were measured in blood samples. Statistical analyses were performed to identify significant differences in allele frequencies and cytokine responses between the groups. <i>Results:</i> Risk alleles (DQB1*0201:0301, OR = 19.4 and DQA1*0101:0501, OR = 4.2) and protective alleles (DRB1*07:13, OR = 0.19, DRB1*01:13, OR = 0.09, DRB1*04:11, OR = 0.07, and DQA1*0501:0501, OR = 0.24) showed statistically significant differences in frequency (<i>p</i> < 0.05) between PLWH and healthy controls. The protective DQA1*0501:0501 allele was associated with elevated levels of IL-1β (<i>p</i> < 0.001, r = 0.79) and IL-10 (<i>p</i> = 0.010, r = 0.63). Increased IL-1β levels may enhance immune responses, while higher IL-10 levels may exert anti-inflammatory effects, potentially reducing susceptibility to HIV-related dermatoses. Regression analysis revealed that IL-1β (Exp(B) = 0.76, <i>p</i> < 0.001) and IFN-γ (Exp(B) = 1.06, <i>p</i> = 0.043) are significant predictors for the likelihood of developing HIV-related dermatoses. An increase in IL-1β levels reduced this likelihood by 24%, while an increase in IFN-γ levels increased it by 6%. <i>Conclusions:</i> The findings emphasize the interaction between HLA class II alleles and cytokine profiles in determining genetic risk and clinical outcomes in PLWH with HIV-related skin disorders. Protective alleles, such as DQA1*0501:0501, may contribute to immune regulation, offering potential targets for therapeutic interventions in PLWH with dermatoses. Our results highlight the importance of IL-1β and IFN-γ as key modulators in the progression of HIV infection and the development of HIV-related dermatoses. Further research is needed to explore the mechanisms underlying these associations, particularly in the Latvian population, to inform targeted therapeutic strategies. |
| format | Article |
| id | doaj-art-c1a4b25c2a434debbdb8a412070e5e59 |
| institution | OA Journals |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-c1a4b25c2a434debbdb8a412070e5e592025-08-20T02:20:58ZengMDPI AGMedicina1010-660X1648-91442025-06-01616109110.3390/medicina61061091Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in LatviaAlena Soha0Inga Azina1Maksims Zolovs2Darja Arina Miskina3Viktorija Murasko4Baiba Rozentale5Ilona Hartmane6Andris Rubins7Doctoral Program, Riga Stradiņš University, LV-1007 Riga, LatviaLatvian Center for Infectious Diseases, Riga East University Hospital, LV-1038 Riga, LatviaStatistics Unit, Riga Stradiņš University, LV-1007 Riga, LatviaResidency Program, University of Latvia, LV-1586 Riga, LatviaResidency Program, University of Latvia, LV-1586 Riga, LatviaLatvian Center for Infectious Diseases, Riga East University Hospital, LV-1038 Riga, LatviaDepartment of Dermatology and Venerology, Riga Stradiņš University, LV-1007 Riga, LatviaFaculty of Medicine, University of Latvia, LV-1586 Riga, Latvia<i>Background and Objectives:</i> This study explores the immunogenetic associations of human leukocyte antigens (HLAs) and cytokine levels in people living with HIV/AIDS (PLWH) who exhibit HIV-related skin disorders. HIV-related skin disorders, including inflammatory eruptions, atopic and seborrheic dermatitis, psoriasis, and pruritic papular eruption, are common among PLWH. These conditions may be influenced by genetic and immunological factors. This study aims to investigate the associations between HLA class II alleles, cytokine levels, and the presence of HIV-related dermatoses, providing insights into genetic susceptibility and immune mechanisms. <i>Materials and Methods:</i> This study included 115 PLWH with HIV-related skin disorders and a control group of 80 healthy individuals. HLA allele frequencies were analyzed, and cytokine levels (IL-1β, IL-10, IFN-y) were measured in blood samples. Statistical analyses were performed to identify significant differences in allele frequencies and cytokine responses between the groups. <i>Results:</i> Risk alleles (DQB1*0201:0301, OR = 19.4 and DQA1*0101:0501, OR = 4.2) and protective alleles (DRB1*07:13, OR = 0.19, DRB1*01:13, OR = 0.09, DRB1*04:11, OR = 0.07, and DQA1*0501:0501, OR = 0.24) showed statistically significant differences in frequency (<i>p</i> < 0.05) between PLWH and healthy controls. The protective DQA1*0501:0501 allele was associated with elevated levels of IL-1β (<i>p</i> < 0.001, r = 0.79) and IL-10 (<i>p</i> = 0.010, r = 0.63). Increased IL-1β levels may enhance immune responses, while higher IL-10 levels may exert anti-inflammatory effects, potentially reducing susceptibility to HIV-related dermatoses. Regression analysis revealed that IL-1β (Exp(B) = 0.76, <i>p</i> < 0.001) and IFN-γ (Exp(B) = 1.06, <i>p</i> = 0.043) are significant predictors for the likelihood of developing HIV-related dermatoses. An increase in IL-1β levels reduced this likelihood by 24%, while an increase in IFN-γ levels increased it by 6%. <i>Conclusions:</i> The findings emphasize the interaction between HLA class II alleles and cytokine profiles in determining genetic risk and clinical outcomes in PLWH with HIV-related skin disorders. Protective alleles, such as DQA1*0501:0501, may contribute to immune regulation, offering potential targets for therapeutic interventions in PLWH with dermatoses. Our results highlight the importance of IL-1β and IFN-γ as key modulators in the progression of HIV infection and the development of HIV-related dermatoses. Further research is needed to explore the mechanisms underlying these associations, particularly in the Latvian population, to inform targeted therapeutic strategies.https://www.mdpi.com/1648-9144/61/6/1091HIVskin disordersDQA1DQB1DRB1cytokines |
| spellingShingle | Alena Soha Inga Azina Maksims Zolovs Darja Arina Miskina Viktorija Murasko Baiba Rozentale Ilona Hartmane Andris Rubins Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia Medicina HIV skin disorders DQA1 DQB1 DRB1 cytokines |
| title | Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia |
| title_full | Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia |
| title_fullStr | Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia |
| title_full_unstemmed | Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia |
| title_short | Association Between HLA Class II Gene Polymorphisms and Cytokine Levels in PLWH with HIV-Related Dermatoses in Latvia |
| title_sort | association between hla class ii gene polymorphisms and cytokine levels in plwh with hiv related dermatoses in latvia |
| topic | HIV skin disorders DQA1 DQB1 DRB1 cytokines |
| url | https://www.mdpi.com/1648-9144/61/6/1091 |
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