Subjective assessment of sleep quality in adult patients with hereditary angioedema
BackgroundHereditary angioedema (HAE) is a rare disorder characterized by recurrent swelling episodes, including painful abdominal attacks and life-threatening angioedema of the larynx that significantly affects patients’ quality of life, including sleep. Sleep disorders have not yet been elucidated...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1555562/full |
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| author | Esra Karabiber Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ahmet Özen Ahmet Özen Ahmet Özen Safa Barış Safa Barış Safa Barış Elif Karakoc-Aydiner Elif Karakoc-Aydiner Elif Karakoc-Aydiner |
| author_facet | Esra Karabiber Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ahmet Özen Ahmet Özen Ahmet Özen Safa Barış Safa Barış Safa Barış Elif Karakoc-Aydiner Elif Karakoc-Aydiner Elif Karakoc-Aydiner |
| author_sort | Esra Karabiber |
| collection | DOAJ |
| description | BackgroundHereditary angioedema (HAE) is a rare disorder characterized by recurrent swelling episodes, including painful abdominal attacks and life-threatening angioedema of the larynx that significantly affects patients’ quality of life, including sleep. Sleep disorders have not yet been elucidated in HAE patients.MethodsThis study evaluated sleep quality and insomnia by comparing attack-free periods with abdominal, head-neck, and extremity attacks. Sleep quality and insomnia were assessed using two validated questionnaires with the Basic Scale on Insomnia and Quality of Sleep (BaSIQS) and the Pittsburgh Sleep Quality Index (PSQI): sleep latency, difficulty falling asleep, night awakenings, problems returning to sleep, and overall sleep quality.ResultsThe study included 23 HAE patients; the median age was 31 years [interquartile range (IQR): 25–37], with a female predominance (n = 16, 69.5%). During the attack-free period, the median PSQI total score was 5 (IQR: 3.75 7.25), with 56.2% of the participants (n = 13) classified as good sleepers. Total PSQI scores significantly increased during attack periods compared to the attack-free period (median: 10 for abdomen, 8.5 for extremities, and 7.5 for head-neck; p < 0.001 for all). Whereas during the attack-free period, only 40.9% of patients exhibited good sleep quality (BaSIQS <9), with a median score of 10 (IQR: 7–14.2).Scores of BaSIQS significantly increased during angioedema attacks, with medians of 15 (extremity), 16 (abdominal), and 17 (head-neck), reflecting a notable decline in sleep quality. Among the components of PSQI, compared to the attack-free period, scores except the one assessing the need for medication to sleep all domains showed statistically significant increase.ConclusionThis study demonstrates that poor sleep quality, prolonged sleep latency, and increased awakenings are prevalent among HAE patients. Screening for sleep disorders and targeted interventions may help improve disease control and overall quality of life in HAE patients. |
| format | Article |
| id | doaj-art-c1a0181249024737be0ea7a53a89a72a |
| institution | OA Journals |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| spelling | doaj-art-c1a0181249024737be0ea7a53a89a72a2025-08-20T02:17:34ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-04-011610.3389/fneur.2025.15555621555562Subjective assessment of sleep quality in adult patients with hereditary angioedemaEsra Karabiber0Ezgi Yalçın Güngören1Ezgi Yalçın Güngören2Ezgi Yalçın Güngören3Ahmet Özen4Ahmet Özen5Ahmet Özen6Safa Barış7Safa Barış8Safa Barış9Elif Karakoc-Aydiner10Elif Karakoc-Aydiner11Elif Karakoc-Aydiner12Department of Chest Disease, Division of Adult Allergy and Immunology, Pendik Training and Research Hospital, Istanbul, TürkiyeDivision of Pediatric Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, TürkiyeThe Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, TürkiyeThe Isil Berat Barlan Center for Translational Medicine, Istanbul, TürkiyeDivision of Pediatric Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, TürkiyeThe Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, TürkiyeThe Isil Berat Barlan Center for Translational Medicine, Istanbul, TürkiyeDivision of Pediatric Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, TürkiyeThe Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, TürkiyeThe Isil Berat Barlan Center for Translational Medicine, Istanbul, TürkiyeDivision of Pediatric Allergy and Immunology, Department of Pediatrics, School of Medicine, Marmara University, Istanbul, TürkiyeThe Istanbul Jeffrey Modell Diagnostic Center for Primary Immunodeficiency Diseases, Istanbul, TürkiyeThe Isil Berat Barlan Center for Translational Medicine, Istanbul, TürkiyeBackgroundHereditary angioedema (HAE) is a rare disorder characterized by recurrent swelling episodes, including painful abdominal attacks and life-threatening angioedema of the larynx that significantly affects patients’ quality of life, including sleep. Sleep disorders have not yet been elucidated in HAE patients.MethodsThis study evaluated sleep quality and insomnia by comparing attack-free periods with abdominal, head-neck, and extremity attacks. Sleep quality and insomnia were assessed using two validated questionnaires with the Basic Scale on Insomnia and Quality of Sleep (BaSIQS) and the Pittsburgh Sleep Quality Index (PSQI): sleep latency, difficulty falling asleep, night awakenings, problems returning to sleep, and overall sleep quality.ResultsThe study included 23 HAE patients; the median age was 31 years [interquartile range (IQR): 25–37], with a female predominance (n = 16, 69.5%). During the attack-free period, the median PSQI total score was 5 (IQR: 3.75 7.25), with 56.2% of the participants (n = 13) classified as good sleepers. Total PSQI scores significantly increased during attack periods compared to the attack-free period (median: 10 for abdomen, 8.5 for extremities, and 7.5 for head-neck; p < 0.001 for all). Whereas during the attack-free period, only 40.9% of patients exhibited good sleep quality (BaSIQS <9), with a median score of 10 (IQR: 7–14.2).Scores of BaSIQS significantly increased during angioedema attacks, with medians of 15 (extremity), 16 (abdominal), and 17 (head-neck), reflecting a notable decline in sleep quality. Among the components of PSQI, compared to the attack-free period, scores except the one assessing the need for medication to sleep all domains showed statistically significant increase.ConclusionThis study demonstrates that poor sleep quality, prolonged sleep latency, and increased awakenings are prevalent among HAE patients. Screening for sleep disorders and targeted interventions may help improve disease control and overall quality of life in HAE patients.https://www.frontiersin.org/articles/10.3389/fneur.2025.1555562/fullhereditary angioedemainsomniasleep qualitysleep disorderssleep disturbance |
| spellingShingle | Esra Karabiber Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ezgi Yalçın Güngören Ahmet Özen Ahmet Özen Ahmet Özen Safa Barış Safa Barış Safa Barış Elif Karakoc-Aydiner Elif Karakoc-Aydiner Elif Karakoc-Aydiner Subjective assessment of sleep quality in adult patients with hereditary angioedema Frontiers in Neurology hereditary angioedema insomnia sleep quality sleep disorders sleep disturbance |
| title | Subjective assessment of sleep quality in adult patients with hereditary angioedema |
| title_full | Subjective assessment of sleep quality in adult patients with hereditary angioedema |
| title_fullStr | Subjective assessment of sleep quality in adult patients with hereditary angioedema |
| title_full_unstemmed | Subjective assessment of sleep quality in adult patients with hereditary angioedema |
| title_short | Subjective assessment of sleep quality in adult patients with hereditary angioedema |
| title_sort | subjective assessment of sleep quality in adult patients with hereditary angioedema |
| topic | hereditary angioedema insomnia sleep quality sleep disorders sleep disturbance |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1555562/full |
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