The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study
Ovarian insufficiency is a significant cause of infertility in women, with limited effective treatment options. Platelet-Rich Plasma (PRP), rich in concentrated growth factors, has shown regenerative potential in various medical fields. However, its efficacy as an adjunct in infertility treatment,...
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| Format: | Article |
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Tehran University of Medical Sciences
2025-01-01
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| Series: | Acta Medica Iranica |
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| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/11420 |
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| author | Zahra Mohammad Alipour Farahnazsadat Ahmadi Sina Mohajernoei Roghaye Gharaei Nazanin Hojjati Elham Shirali Firouzeh Akbari Asbagh |
| author_facet | Zahra Mohammad Alipour Farahnazsadat Ahmadi Sina Mohajernoei Roghaye Gharaei Nazanin Hojjati Elham Shirali Firouzeh Akbari Asbagh |
| author_sort | Zahra Mohammad Alipour |
| collection | DOAJ |
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Ovarian insufficiency is a significant cause of infertility in women, with limited effective treatment options. Platelet-Rich Plasma (PRP), rich in concentrated growth factors, has shown regenerative potential in various medical fields. However, its efficacy as an adjunct in infertility treatment, particularly in women with ovarian insufficiency, remains unclear. This study investigates whether PRP administration improves the success of IVF cycles in this specific population. This cohort study followed women with ovarian insufficiency undergoing IVF at a fertility center. Participants were divided into two groups: the intervention group, which received PRP alongside the standard IVF protocol, and the control group, which received only the standard protocol. Data collected included patient demographics, hormonal levels, number and quality of retrieved oocytes, fertilization rates, embryo quality, and pregnancy outcomes. The primary outcome was IVF success, defined by clinical pregnancy rates. Secondary outcomes included hormonal changes, oocyte quality, and embryo development. Statistical analysis utilized descriptive statistics, chi-square tests, and t-tests to compare outcomes between groups. PRP administration led to significant reductions in FSH levels (P<0.001) and marked increases in AMH levels and antral follicle count (AFC) (P=0.001 and P<0.001, respectively). The number of oocytes, mature MII oocytes, and Grade A embryos also improved significantly (P ranging from 0.004 to 0.017). Although the increase in Grade B embryos was not statistically significant, it was higher post-PRP. Chemical pregnancies occurred in 25% of participants, with 20.83% resulting in clinical pregnancies, including 2.1% spontaneous pregnancies. PRP significantly enhanced ovarian reserve markers (FSH, AMH, AFC), oocyte quality, and embryo development, translating into improved fertility outcomes. The findings suggest that with longer follow-up and larger sample sizes, PRP could be validated as a promising adjunctive therapy for women with ovarian insufficiency undergoing IVF. These results align with prior research and highlight PRP’s potential to advance reproductive outcomes in this challenging patient population.
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| format | Article |
| id | doaj-art-c198e745ddaa49ae91b3e4c835bd6c45 |
| institution | Kabale University |
| issn | 0044-6025 1735-9694 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tehran University of Medical Sciences |
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| series | Acta Medica Iranica |
| spelling | doaj-art-c198e745ddaa49ae91b3e4c835bd6c452025-02-09T08:50:52ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942025-01-0162510.18502/acta.v62i5.17774The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort StudyZahra Mohammad Alipour0Farahnazsadat Ahmadi1Sina Mohajernoei2Roghaye Gharaei3Nazanin Hojjati4Elham Shirali5Firouzeh Akbari Asbagh6Department of Obstetrics and Gynecology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran .Department of Obstetrics and Gynecology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran .Department of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.Department of Obstetrics and Gynecology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.Department of Obstetrics and Gynecology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.Department of Gynecologic Oncology, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, School of Medicine, Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran Ovarian insufficiency is a significant cause of infertility in women, with limited effective treatment options. Platelet-Rich Plasma (PRP), rich in concentrated growth factors, has shown regenerative potential in various medical fields. However, its efficacy as an adjunct in infertility treatment, particularly in women with ovarian insufficiency, remains unclear. This study investigates whether PRP administration improves the success of IVF cycles in this specific population. This cohort study followed women with ovarian insufficiency undergoing IVF at a fertility center. Participants were divided into two groups: the intervention group, which received PRP alongside the standard IVF protocol, and the control group, which received only the standard protocol. Data collected included patient demographics, hormonal levels, number and quality of retrieved oocytes, fertilization rates, embryo quality, and pregnancy outcomes. The primary outcome was IVF success, defined by clinical pregnancy rates. Secondary outcomes included hormonal changes, oocyte quality, and embryo development. Statistical analysis utilized descriptive statistics, chi-square tests, and t-tests to compare outcomes between groups. PRP administration led to significant reductions in FSH levels (P<0.001) and marked increases in AMH levels and antral follicle count (AFC) (P=0.001 and P<0.001, respectively). The number of oocytes, mature MII oocytes, and Grade A embryos also improved significantly (P ranging from 0.004 to 0.017). Although the increase in Grade B embryos was not statistically significant, it was higher post-PRP. Chemical pregnancies occurred in 25% of participants, with 20.83% resulting in clinical pregnancies, including 2.1% spontaneous pregnancies. PRP significantly enhanced ovarian reserve markers (FSH, AMH, AFC), oocyte quality, and embryo development, translating into improved fertility outcomes. The findings suggest that with longer follow-up and larger sample sizes, PRP could be validated as a promising adjunctive therapy for women with ovarian insufficiency undergoing IVF. These results align with prior research and highlight PRP’s potential to advance reproductive outcomes in this challenging patient population. https://acta.tums.ac.ir/index.php/acta/article/view/11420InfertilityOvarian insufficiencyPlatelet-rich plasma (PRP)In vitro fertilization (IVF)Oocyte qualityEmbryo quality |
| spellingShingle | Zahra Mohammad Alipour Farahnazsadat Ahmadi Sina Mohajernoei Roghaye Gharaei Nazanin Hojjati Elham Shirali Firouzeh Akbari Asbagh The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study Acta Medica Iranica Infertility Ovarian insufficiency Platelet-rich plasma (PRP) In vitro fertilization (IVF) Oocyte quality Embryo quality |
| title | The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study |
| title_full | The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study |
| title_fullStr | The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study |
| title_full_unstemmed | The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study |
| title_short | The Role of Platelet-Rich Plasma (PRP) in Enhancing IVF Success in Women With Ovarian Insufficiency: A Cohort Study |
| title_sort | role of platelet rich plasma prp in enhancing ivf success in women with ovarian insufficiency a cohort study |
| topic | Infertility Ovarian insufficiency Platelet-rich plasma (PRP) In vitro fertilization (IVF) Oocyte quality Embryo quality |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/11420 |
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