Giant cell tumor of the bone with fatal pulmonary metastasis: A case report
Giant cell tumors of the bone are typically benign, locally aggressive lesions that rarely metastasize. In this report, we describe the case of a 48-year-old woman presenting with a giant cell tumor of the bone of the hip joint, which demonstrated aggressive histological features and recurrent behav...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-07-01
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| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251364130 |
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| author | Mohamad Taha Saadia A. Faiz Pushan Jani Jing Liu Yasir D. Ali Mohammad Asim Amjad |
| author_facet | Mohamad Taha Saadia A. Faiz Pushan Jani Jing Liu Yasir D. Ali Mohammad Asim Amjad |
| author_sort | Mohamad Taha |
| collection | DOAJ |
| description | Giant cell tumors of the bone are typically benign, locally aggressive lesions that rarely metastasize. In this report, we describe the case of a 48-year-old woman presenting with a giant cell tumor of the bone of the hip joint, which demonstrated aggressive histological features and recurrent behavior. The patient developed multiple unresectable pulmonary metastases despite several wide local excisions. Although pulmonary metastases from giant cell tumors of the bone are usually associated with a relatively favorable prognosis, guidelines for the optimal treatment of metastatic giant cell tumors of the bone remain limited. This case highlights the unpredictable nature of giant cell tumors of the bone and emphasizes the need for alternative treatment options in those with resistance to traditional therapies. |
| format | Article |
| id | doaj-art-c1950c6561fb418b802bf5c963b24b13 |
| institution | DOAJ |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-c1950c6561fb418b802bf5c963b24b132025-08-20T03:16:01ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-07-011310.1177/2050313X251364130Giant cell tumor of the bone with fatal pulmonary metastasis: A case reportMohamad Taha0Saadia A. Faiz1Pushan Jani2Jing Liu3Yasir D. Ali4Mohammad Asim Amjad5College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USADepartment of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USADivisions of Pulmonary, Critical Care Medicine and Sleep Medicine, McGovern Medical School, University of Texas Health Houston, TX, USADepartment of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Houston, TX, USADepartment of Pathology and Laboratory Medicine, McGovern Medical School, University of Texas Health Houston, TX, USADivisions of Pulmonary, Critical Care Medicine and Sleep Medicine, McGovern Medical School, University of Texas Health Houston, TX, USAGiant cell tumors of the bone are typically benign, locally aggressive lesions that rarely metastasize. In this report, we describe the case of a 48-year-old woman presenting with a giant cell tumor of the bone of the hip joint, which demonstrated aggressive histological features and recurrent behavior. The patient developed multiple unresectable pulmonary metastases despite several wide local excisions. Although pulmonary metastases from giant cell tumors of the bone are usually associated with a relatively favorable prognosis, guidelines for the optimal treatment of metastatic giant cell tumors of the bone remain limited. This case highlights the unpredictable nature of giant cell tumors of the bone and emphasizes the need for alternative treatment options in those with resistance to traditional therapies.https://doi.org/10.1177/2050313X251364130 |
| spellingShingle | Mohamad Taha Saadia A. Faiz Pushan Jani Jing Liu Yasir D. Ali Mohammad Asim Amjad Giant cell tumor of the bone with fatal pulmonary metastasis: A case report SAGE Open Medical Case Reports |
| title | Giant cell tumor of the bone with fatal pulmonary metastasis: A case report |
| title_full | Giant cell tumor of the bone with fatal pulmonary metastasis: A case report |
| title_fullStr | Giant cell tumor of the bone with fatal pulmonary metastasis: A case report |
| title_full_unstemmed | Giant cell tumor of the bone with fatal pulmonary metastasis: A case report |
| title_short | Giant cell tumor of the bone with fatal pulmonary metastasis: A case report |
| title_sort | giant cell tumor of the bone with fatal pulmonary metastasis a case report |
| url | https://doi.org/10.1177/2050313X251364130 |
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