Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects
Hyperlipidemia represents a global metabolic epidemic with increasing prevalence, profoundly associated with the etiology of cardiovascular and cerebrovascular diseases. This study investigates the therapeutic potential of two widely distributed bioactive polyphenols, Cyanidin-3-O-glucoside (C3G), c...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1637637/full |
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| author | Hangyu Liu Tienan Xiang Qianxi Zang Qianxi Zang Meihong Liu Meihong Liu Yuying Wang Yuying Wang Wandi Yin Wandi Yin Jingsheng Liu Jingsheng Liu |
| author_facet | Hangyu Liu Tienan Xiang Qianxi Zang Qianxi Zang Meihong Liu Meihong Liu Yuying Wang Yuying Wang Wandi Yin Wandi Yin Jingsheng Liu Jingsheng Liu |
| author_sort | Hangyu Liu |
| collection | DOAJ |
| description | Hyperlipidemia represents a global metabolic epidemic with increasing prevalence, profoundly associated with the etiology of cardiovascular and cerebrovascular diseases. This study investigates the therapeutic potential of two widely distributed bioactive polyphenols, Cyanidin-3-O-glucoside (C3G), catechin, and their synergistic combinatorial formation (C3G-catechin) in modulating hyperlipidemia, using complementary in vitro models (Caco-2 monolayer and Caco-2/HepG2 co-culture systems) to simulate intestinal absorption dynamics and lipid metabolic regulation. Our results reveal that the intestinal absorption efficiency follows the order of catechin > C3G-catechin > C3G, primarily mediated through passive diffusion. Furthermore, these polyphenols exhibited significant hypolipidemic effects by downregulating the transcriptional and translational levels of lipid metabolism-related genes, such as SREBP-1, PPARγ, and FAS. This downregulation led to a reduction in key metabolites, including total cholesterol, triglycerides, and LDL-C. Notably, the C3G-catechin combination demonstrated superior regulatory efficacy compared to the individual compounds, suggesting synergistic bioactivity. This study provides mechanistic insights into the enteric transport dynamics and metabolic modulation of dietary polyphenols, highlighting their therapeutic potential to reduce harmful cholesterol level. These findings propose new perspectives for developing nutritional health foods aimed at preventing and treating hyperlipidemia. |
| format | Article |
| id | doaj-art-c1926da774ce49f58749f1bdb4d6a7ce |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-c1926da774ce49f58749f1bdb4d6a7ce2025-08-20T03:47:04ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-08-011210.3389/fnut.2025.16376371637637Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effectsHangyu Liu0Tienan Xiang1Qianxi Zang2Qianxi Zang3Meihong Liu4Meihong Liu5Yuying Wang6Yuying Wang7Wandi Yin8Wandi Yin9Jingsheng Liu10Jingsheng Liu11College of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaCollege of Grain, Oil and Food, Jilin Engineering Vocational College, Siping, Jilin, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaNational Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaNational Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaNational Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaNational Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, ChinaCollege of Food Science and Engineering, Jilin Agricultural University, Changchun, Jilin, ChinaNational Engineering Research Center for Wheat and Corn Deep Processing, Changchun, Jilin, ChinaHyperlipidemia represents a global metabolic epidemic with increasing prevalence, profoundly associated with the etiology of cardiovascular and cerebrovascular diseases. This study investigates the therapeutic potential of two widely distributed bioactive polyphenols, Cyanidin-3-O-glucoside (C3G), catechin, and their synergistic combinatorial formation (C3G-catechin) in modulating hyperlipidemia, using complementary in vitro models (Caco-2 monolayer and Caco-2/HepG2 co-culture systems) to simulate intestinal absorption dynamics and lipid metabolic regulation. Our results reveal that the intestinal absorption efficiency follows the order of catechin > C3G-catechin > C3G, primarily mediated through passive diffusion. Furthermore, these polyphenols exhibited significant hypolipidemic effects by downregulating the transcriptional and translational levels of lipid metabolism-related genes, such as SREBP-1, PPARγ, and FAS. This downregulation led to a reduction in key metabolites, including total cholesterol, triglycerides, and LDL-C. Notably, the C3G-catechin combination demonstrated superior regulatory efficacy compared to the individual compounds, suggesting synergistic bioactivity. This study provides mechanistic insights into the enteric transport dynamics and metabolic modulation of dietary polyphenols, highlighting their therapeutic potential to reduce harmful cholesterol level. These findings propose new perspectives for developing nutritional health foods aimed at preventing and treating hyperlipidemia.https://www.frontiersin.org/articles/10.3389/fnut.2025.1637637/fullpolyphenolscyanidin-3-O-glucosidecatechincholesterollipid metabolismhyperlipidemia |
| spellingShingle | Hangyu Liu Tienan Xiang Qianxi Zang Qianxi Zang Meihong Liu Meihong Liu Yuying Wang Yuying Wang Wandi Yin Wandi Yin Jingsheng Liu Jingsheng Liu Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects Frontiers in Nutrition polyphenols cyanidin-3-O-glucoside catechin cholesterol lipid metabolism hyperlipidemia |
| title | Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects |
| title_full | Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects |
| title_fullStr | Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects |
| title_full_unstemmed | Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects |
| title_short | Synergy analysis of cyanidin-3-O-glucoside and catechin: absorption, transport and lipid metabolism effects |
| title_sort | synergy analysis of cyanidin 3 o glucoside and catechin absorption transport and lipid metabolism effects |
| topic | polyphenols cyanidin-3-O-glucoside catechin cholesterol lipid metabolism hyperlipidemia |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1637637/full |
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