Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study
ABSTRACT Purpose Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first‐episode,...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.70416 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849764055480270848 |
|---|---|
| author | Wenjie Zhang Chan Zhang Jinyuan Zhao Jiajing Cui Jinji Bai Xuan Deng Junjun Ji Ting Li Yu Wang Kefeng Li Yunhui Qu Junfeng Li |
| author_facet | Wenjie Zhang Chan Zhang Jinyuan Zhao Jiajing Cui Jinji Bai Xuan Deng Junjun Ji Ting Li Yu Wang Kefeng Li Yunhui Qu Junfeng Li |
| author_sort | Wenjie Zhang |
| collection | DOAJ |
| description | ABSTRACT Purpose Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first‐episode, treatment‐naïve adolescents with MDD using an integrated diffusion tensor imaging (DTI) approach. Method We recruited 66 subjects, including 37 adolescents with MDD and 29 healthy controls. Two main DTI techniques, automated fiber quantification (AFQ) and tract‐based spatial statistics (TBSS), were used to analyze fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) in WM tracts. DTI measures were then correlated with the depressive symptoms evaluated by Hamilton Depression Rating Scale scores (HAMD‐17). Findings In AFQ, MDD patients showed significant segmental differences in WM tracts compared to controls, including a negative correlation between SLF AD values and depression severity. TBSS revealed reduced FA in the cingulum, forceps minor, inferior fronto‐occipital fasciculus, inferior longitudinal fasciculus, SLF, and uncinate fasciculus in MDD. Conclusion Our integrated DTI analysis in a unique first‐episode, medication‐naïve cohort revealed microstructural changes in adolescent MDD not previously reported. These findings may provide imaging markers for early detection and enhance our understanding of depression pathology in youth. |
| format | Article |
| id | doaj-art-c19076305e5e47feb4839aa61b6181e3 |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-c19076305e5e47feb4839aa61b6181e32025-08-20T03:05:14ZengWileyBrain and Behavior2162-32792025-03-01153n/an/a10.1002/brb3.70416Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS StudyWenjie Zhang0Chan Zhang1Jinyuan Zhao2Jiajing Cui3Jinji Bai4Xuan Deng5Junjun Ji6Ting Li7Yu Wang8Kefeng Li9Yunhui Qu10Junfeng Li11Department of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaDepartment of PsychiatryChangzhi Mental Health CenterChangzhiShanxiChinaFaculty of Applied SciencesMacao Polytechnic UniversityMacao SARChinaDepartment of Radiology, Yantai Yuhuangding HospitalQingdao UniversityYantaiShandongChinaDepartment of RadiologyHeping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxiChinaABSTRACT Purpose Structural changes during depressive episodes in adolescents with major depressive disorder (MDD) remains unclear due to participant heterogeneity, illness chronicity, and medication confounders. This study aimed to explore white matter (WM) microstructural changes in first‐episode, treatment‐naïve adolescents with MDD using an integrated diffusion tensor imaging (DTI) approach. Method We recruited 66 subjects, including 37 adolescents with MDD and 29 healthy controls. Two main DTI techniques, automated fiber quantification (AFQ) and tract‐based spatial statistics (TBSS), were used to analyze fractional anisotropy (FA), axial diffusivity (AD), radial diffusivity (RD), and mean diffusivity (MD) in WM tracts. DTI measures were then correlated with the depressive symptoms evaluated by Hamilton Depression Rating Scale scores (HAMD‐17). Findings In AFQ, MDD patients showed significant segmental differences in WM tracts compared to controls, including a negative correlation between SLF AD values and depression severity. TBSS revealed reduced FA in the cingulum, forceps minor, inferior fronto‐occipital fasciculus, inferior longitudinal fasciculus, SLF, and uncinate fasciculus in MDD. Conclusion Our integrated DTI analysis in a unique first‐episode, medication‐naïve cohort revealed microstructural changes in adolescent MDD not previously reported. These findings may provide imaging markers for early detection and enhance our understanding of depression pathology in youth.https://doi.org/10.1002/brb3.70416adolescentsautomated fiber quantificationdiffusion tensor imagingmajor depressive disordertract‐based spatial statistics |
| spellingShingle | Wenjie Zhang Chan Zhang Jinyuan Zhao Jiajing Cui Jinji Bai Xuan Deng Junjun Ji Ting Li Yu Wang Kefeng Li Yunhui Qu Junfeng Li Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study Brain and Behavior adolescents automated fiber quantification diffusion tensor imaging major depressive disorder tract‐based spatial statistics |
| title | Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study |
| title_full | Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study |
| title_fullStr | Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study |
| title_full_unstemmed | Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study |
| title_short | Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First‐Episode, Treatment‐Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study |
| title_sort | microstructure abnormalities of diffusion tensor imaging measures in first episode treatment naive adolescents with major depressive disorder an integrated afq and tbss study |
| topic | adolescents automated fiber quantification diffusion tensor imaging major depressive disorder tract‐based spatial statistics |
| url | https://doi.org/10.1002/brb3.70416 |
| work_keys_str_mv | AT wenjiezhang microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT chanzhang microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT jinyuanzhao microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT jiajingcui microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT jinjibai microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT xuandeng microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT junjunji microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT tingli microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT yuwang microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT kefengli microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT yunhuiqu microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy AT junfengli microstructureabnormalitiesofdiffusiontensorimagingmeasuresinfirstepisodetreatmentnaiveadolescentswithmajordepressivedisorderanintegratedafqandtbssstudy |