Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

Allosteric modulation by the fatty acid site in the glycosylated SARS-CoV-2 spike

The spike protein is essential to the SARS-CoV-2 virus life cycle, facilitating virus entry and mediating viral-host membrane fusion. The spike contains a fatty acid (FA) binding site between every two neighbouring receptor-binding domains. This site is coupled to key regions in the protein, but the...

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Bibliographic Details
Main Authors: A Sofia F Oliveira, Fiona L Kearns, Mia A Rosenfeld, Lorenzo Casalino, Lorenzo Tulli, Imre Berger, Christiane Schaffitzel, Andrew D Davidson, Rommie E Amaro, Adrian J Mulholland
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
allostery
SARS-CoV-2 spike
glycans
nonequilibrium simulations
fatty acids
Online Access:https://elifesciences.org/articles/97313
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