Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis

Gut microbiota-driven pathogenic Th17 cells mediated autoimmune epididymo-orchitis in a mouse model of colitis

Summary: Inflammatory bowel disease (IBD) is linked to male fertility disorders, yet the role of gut microbiota dysbiosis remains underexplored. Here, we investigated how dysbiosis contributes to autoimmune epididymo-orchitis in a colitis mouse model induced by CD4+ T cell transfer. We transferred w...

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Bibliographic Details
Main Authors: Qunxiong Zeng, Jin-Chuan Liu, Chen Yang, Minmin Lyu, Dongliang Li, William S.B. Yeung, Philip C.N. Chiu, Tao Zhang, Yong-Gang Duan
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Biological sciences
Immunology
Immune system
Immune response
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225007692
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