Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer
Objective. Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. Methods. We retrieved 145 cases of GC who had un...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5905173 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567961337987072 |
|---|---|
| author | Der Sheng Sun Soon Auck Hong Hye Sung Won Su Hyun Yoo Han Hong Lee Okran Kim Yoon Ho Ko |
| author_facet | Der Sheng Sun Soon Auck Hong Hye Sung Won Su Hyun Yoo Han Hong Lee Okran Kim Yoon Ho Ko |
| author_sort | Der Sheng Sun |
| collection | DOAJ |
| description | Objective. Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. Methods. We retrieved 145 cases of GC who had undergone curative gastrectomy. The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed. Results. High expression of Cav-1 protein of the GC in the stomach and metastatic lymph node was 12.4% (18/145) and 16.5% (15/91). In the multivariate analysis, tumoral Cav-1 protein in metastatic lymph node showed prognostic significance for relapse-free survival (RFS, HR, 3.934; 95% CI, 1.882–8.224; P=0.001) and cancer-specific survival outcome (CSS, HR, 2.681; 95% CI, 1.613–8.623; P=0.002). Among the GCs with metastatic lymph node, it remained as a strong indicator of poor prognosis for RFS (HR, 3.136; 95% CI, 1.444–6.810; P=0.004) and CSS (HR, 2.509; 95% CI, 1.078–5.837; P=0.032). Conclusion. High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers. |
| format | Article |
| id | doaj-art-c185956938134dacaba4602ef10f4511 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c185956938134dacaba4602ef10f45112025-02-03T01:00:02ZengWileyGastroenterology Research and Practice1687-61211687-630X2017-01-01201710.1155/2017/59051735905173Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric CancerDer Sheng Sun0Soon Auck Hong1Hye Sung Won2Su Hyun Yoo3Han Hong Lee4Okran Kim5Yoon Ho Ko6Division of Oncology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Pathology, Soonchunhyang Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Republic of KoreaDivision of Oncology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDepartment of Hospital Pathology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu-si, Republic of KoreaDepartment of General Surgery, The Catholic University of Korea, Seoul, Republic of KoreaCancer Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of KoreaDivision of Oncology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of KoreaObjective. Caveolin-1 (Cav-1), as the main component of caveolae, has complex roles in tumourigenesis in human malignancies. We investigated Cav-1 in primary and metastatic tumor cells of gastric cancer (GC) and its association with clinical outcomes. Methods. We retrieved 145 cases of GC who had undergone curative gastrectomy. The expression levels of Cav-1 was evaluated by immunohistochemistry, and its association with clinicopathological parameters and patient survival was analyzed. Results. High expression of Cav-1 protein of the GC in the stomach and metastatic lymph node was 12.4% (18/145) and 16.5% (15/91). In the multivariate analysis, tumoral Cav-1 protein in metastatic lymph node showed prognostic significance for relapse-free survival (RFS, HR, 3.934; 95% CI, 1.882–8.224; P=0.001) and cancer-specific survival outcome (CSS, HR, 2.681; 95% CI, 1.613–8.623; P=0.002). Among the GCs with metastatic lymph node, it remained as a strong indicator of poor prognosis for RFS (HR, 3.136; 95% CI, 1.444–6.810; P=0.004) and CSS (HR, 2.509; 95% CI, 1.078–5.837; P=0.032). Conclusion. High expression of tumoral Cav-1 protein in metastatic lymph node is associated with unfavorable prognosis of curative resected GC, indicating the potential of novel prognostic markers.http://dx.doi.org/10.1155/2017/5905173 |
| spellingShingle | Der Sheng Sun Soon Auck Hong Hye Sung Won Su Hyun Yoo Han Hong Lee Okran Kim Yoon Ho Ko Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer Gastroenterology Research and Practice |
| title | Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer |
| title_full | Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer |
| title_fullStr | Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer |
| title_full_unstemmed | Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer |
| title_short | Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer |
| title_sort | prognostic value of metastatic tumoral caveolin 1 expression in patients with resected gastric cancer |
| url | http://dx.doi.org/10.1155/2017/5905173 |
| work_keys_str_mv | AT dershengsun prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT soonauckhong prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT hyesungwon prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT suhyunyoo prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT hanhonglee prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT okrankim prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer AT yoonhoko prognosticvalueofmetastatictumoralcaveolin1expressioninpatientswithresectedgastriccancer |