The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity

The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity

IntroductionCD8+ T cells are vital in the immune control of cancer and a key player in cell-based cancer immunotherapy. Recent studies have shown that microbial short-chain fatty acids (SCFA) can promote both effector and memory phenotypes in CD8+ T cells and may thereby enhance protection against c...

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Bibliographic Details
Main Authors: Douglas A. Gaskarth, Shujun Fan, Andrew J. Highton, Roslyn A. Kemp
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Medicine
Subjects:
butyrate
cancer
CD8+ T cells
activation
effector function
short-chain fatty acids
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1577906/full
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