Interaction between APOE Ɛ4 status, chemotherapy and endocrine therapy on cognitive functioning among breast cancer survivors: the CANTO-Cog longitudinal study

Interaction between APOE Ɛ4 status, chemotherapy and endocrine therapy on cognitive functioning among breast cancer survivors: the CANTO-Cog longitudinal study

Abstract Background Apolipoprotein Ɛ4 genotype (APOE4) has been associated with cancer-related cognitive impairment, but its interaction with treatments remains unclear. This longitudinal study aims to evaluate the association between APOE4 and cognitive impairment in women with breast cancer (BC) u...

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Main Authors: Mylène Duivon, François Christy, Emilie Thomas, Justine Lequesne, Hélène Castel, Catherine Gaudin, Dominique Delmas, Sandrine Boyault, Olivier Rigal, Chayma Bousrih, Christelle Lévy, Florence Lerebours, Antonio Di Meglio, Patricia A. Ganz, Kathleen Van Dyk, Ines Vaz Luis, Marie Lange, Florence Joly
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Breast Cancer Research
Subjects:
Breast cancer
APOE4
Cancer-related cognitive impairment
Endocrine therapy
Chemotherapy
Online Access:https://doi.org/10.1186/s13058-025-01974-2
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