Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases
Background. Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition. Methods. Retrospective analysis of 3 patients wi...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Otolaryngology |
| Online Access: | http://dx.doi.org/10.1155/2023/4788617 |
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| author | W. F. Julius Scheurleer Weibel W. Braunius Bernard M. Tijink Luuk M. Janssen Frank A. Pameijer Gerben E. Breimer Ernst J. Smid Remco de Bree Lot A. Devriese Johannes A. Rijken |
| author_facet | W. F. Julius Scheurleer Weibel W. Braunius Bernard M. Tijink Luuk M. Janssen Frank A. Pameijer Gerben E. Breimer Ernst J. Smid Remco de Bree Lot A. Devriese Johannes A. Rijken |
| author_sort | W. F. Julius Scheurleer |
| collection | DOAJ |
| description | Background. Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition. Methods. Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted. Results. Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease. Conclusion. Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)‐radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option. |
| format | Article |
| id | doaj-art-c1821ff4500b4fe3823705ab9a65c914 |
| institution | Kabale University |
| issn | 2090-6773 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Otolaryngology |
| spelling | doaj-art-c1821ff4500b4fe3823705ab9a65c9142025-02-03T07:26:21ZengWileyCase Reports in Otolaryngology2090-67732023-01-01202310.1155/2023/4788617Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three CasesW. F. Julius Scheurleer0Weibel W. Braunius1Bernard M. Tijink2Luuk M. Janssen3Frank A. Pameijer4Gerben E. Breimer5Ernst J. Smid6Remco de Bree7Lot A. Devriese8Johannes A. Rijken9Department of Head and Neck Surgical OncologyDepartment of Head and Neck Surgical OncologyDepartment of Head and Neck Surgical OncologyDepartment of Head and Neck Surgical OncologyDepartment of RadiologyDepartment of PathologyDepartment of Radiation OncologyDepartment of Head and Neck Surgical OncologyDepartment of Medical OncologyDepartment of Head and Neck Surgical OncologyBackground. Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition. Methods. Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted. Results. Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease. Conclusion. Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)‐radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.http://dx.doi.org/10.1155/2023/4788617 |
| spellingShingle | W. F. Julius Scheurleer Weibel W. Braunius Bernard M. Tijink Luuk M. Janssen Frank A. Pameijer Gerben E. Breimer Ernst J. Smid Remco de Bree Lot A. Devriese Johannes A. Rijken Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases Case Reports in Otolaryngology |
| title | Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases |
| title_full | Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases |
| title_fullStr | Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases |
| title_full_unstemmed | Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases |
| title_short | Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases |
| title_sort | diagnostic and treatment related challenges in sinonasal teratocarcinosarcoma a report of three cases |
| url | http://dx.doi.org/10.1155/2023/4788617 |
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