Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis
Purpose. Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. Methods. 12 pr...
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2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/945317 |
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| author | Marta Sacchetti Alessandro Lambiase Costanzo Moretti Flavio Mantelli Stefano Bonini |
| author_facet | Marta Sacchetti Alessandro Lambiase Costanzo Moretti Flavio Mantelli Stefano Bonini |
| author_sort | Marta Sacchetti |
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| description | Purpose. Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. Methods. 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. Results. Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P<0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P=0.007 and P=0.028, resp.) and SHBG (P=0.01 and P=0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P=0.007). Conclusions and Relevance. VKC patients have different circulating sex hormone levels in different phases of the disease and when compared to nonallergic subjects. These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC. |
| format | Article |
| id | doaj-art-c179e2d3c3774de593b6aed7bf9f160c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-c179e2d3c3774de593b6aed7bf9f160c2025-02-03T05:59:32ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/945317945317Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal KeratoconjunctivitisMarta Sacchetti0Alessandro Lambiase1Costanzo Moretti2Flavio Mantelli3Stefano Bonini4Cornea and Ocular Surface Disease Unit, IRCCS Ospedale San Raffaele, Via Olgettina 60, 20132 Milan, ItalyDepartment of Organi di Senso, Sapienza University, Viale del Policlinico 155, 00161 Rome, ItalyUnit of Endocrinology, Fatebenefratelli Hospital, Isola Tiberina, University of Rome Tor Vergata, 00187 Rome, ItalyIRCCS GB Bietti Eye Foundation, Via Livenza 3, 00198 Rome, ItalyDepartment of Ophthalmology, Università Campus Bio-Medico, Via Álvaro del Portillo 21, 00128 Rome, ItalyPurpose. Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. Methods. 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. Results. Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P<0.001). Prepubertal and early pubertal VKC showed a significant decrease in DHT (P=0.007 and P=0.028, resp.) and SHBG (P=0.01 and P=0.002, resp.) when compared to controls and serum levels of SHBG were increased in late pubertal VKC in remission phase (P=0.007). Conclusions and Relevance. VKC patients have different circulating sex hormone levels in different phases of the disease and when compared to nonallergic subjects. These findings suggest a role played by sex hormones in the pathogenesis and/or activity of VKC.http://dx.doi.org/10.1155/2015/945317 |
| spellingShingle | Marta Sacchetti Alessandro Lambiase Costanzo Moretti Flavio Mantelli Stefano Bonini Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis Journal of Immunology Research |
| title | Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis |
| title_full | Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis |
| title_fullStr | Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis |
| title_full_unstemmed | Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis |
| title_short | Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis |
| title_sort | sex hormones in allergic conjunctivitis altered levels of circulating androgens and estrogens in children and adolescents with vernal keratoconjunctivitis |
| url | http://dx.doi.org/10.1155/2015/945317 |
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