Development of an Orientation-independent Handheld Nebulizer
Abstract This work aimed to develop and evaluate a miniaturized handheld vibrating mesh nebulizer (MHVMN) that functions equally well in any orientation. The MHVMN, which comprises a a power supply unit, a vibrating mesh plate, and a liquid reservoir equipped with either a flat end orifice tube (FEO...
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| Format: | Article |
| Language: | English |
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Springer
2020-09-01
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| Series: | Aerosol and Air Quality Research |
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| Online Access: | https://doi.org/10.4209/aaqr.2020.05.0203 |
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| author | Sheng-Hsiu Huang Chih-Wei Lin Wei-Ren Ke Yu-Mei Kuo Chih-Chieh Chen |
| author_facet | Sheng-Hsiu Huang Chih-Wei Lin Wei-Ren Ke Yu-Mei Kuo Chih-Chieh Chen |
| author_sort | Sheng-Hsiu Huang |
| collection | DOAJ |
| description | Abstract This work aimed to develop and evaluate a miniaturized handheld vibrating mesh nebulizer (MHVMN) that functions equally well in any orientation. The MHVMN, which comprises a a power supply unit, a vibrating mesh plate, and a liquid reservoir equipped with either a flat end orifice tube (FEOT) or a traditional wick for delivery, was primarily tested using deionized water and a 0.9% sodium chloride solution. Since our study focused on optimizing the dimensions of the FEOT, which utilizes capillary action to deliver the solution, we examined the effects of the operating parameters, viz., the gap between the reservoir wall and the FEOT (LLR-FEOT), the diameter of the FEOT’s orifice (Dorifice), the orientation of the nebulizer, and the size of the aperture, on the performance of the device. The output rate and the residual volume were determined gravimetrically, and both the concentration and the mass distribution of the aerosolized particles were measured with an aerosol size spectrometer (welas digital 3000) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). The results revealed an optimal LLR-FEOT of 0.225 mm, which achieved similar output rates and residual volumes across various orientations. Additionally, a Dorifice exceeding 0.8 mm was necessary to ensure continuous nebulization, thereby yielding a residual volume of less than 4%. Using the FEOT instead of a traditional wick also significantly decreased the residual volume—a major advantage in delivering costly drugs. The consistently high efficiency of the MHVMN regardless of orientation demonstrates its suitability for administering aerosolized medication, especially to patients lying in bed. |
| format | Article |
| id | doaj-art-c176557e43e2406781817ef63f896709 |
| institution | Kabale University |
| issn | 1680-8584 2071-1409 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Springer |
| record_format | Article |
| series | Aerosol and Air Quality Research |
| spelling | doaj-art-c176557e43e2406781817ef63f8967092025-02-09T12:20:48ZengSpringerAerosol and Air Quality Research1680-85842071-14092020-09-0121111310.4209/aaqr.2020.05.0203Development of an Orientation-independent Handheld NebulizerSheng-Hsiu Huang0Chih-Wei Lin1Wei-Ren Ke2Yu-Mei Kuo3Chih-Chieh Chen4Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan UniversityInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan UniversityInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan UniversityDepartment of Occupational Safety and Health, Chung Hwa University of Medical TechnologyInstitute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan UniversityAbstract This work aimed to develop and evaluate a miniaturized handheld vibrating mesh nebulizer (MHVMN) that functions equally well in any orientation. The MHVMN, which comprises a a power supply unit, a vibrating mesh plate, and a liquid reservoir equipped with either a flat end orifice tube (FEOT) or a traditional wick for delivery, was primarily tested using deionized water and a 0.9% sodium chloride solution. Since our study focused on optimizing the dimensions of the FEOT, which utilizes capillary action to deliver the solution, we examined the effects of the operating parameters, viz., the gap between the reservoir wall and the FEOT (LLR-FEOT), the diameter of the FEOT’s orifice (Dorifice), the orientation of the nebulizer, and the size of the aperture, on the performance of the device. The output rate and the residual volume were determined gravimetrically, and both the concentration and the mass distribution of the aerosolized particles were measured with an aerosol size spectrometer (welas digital 3000) and a Micro-Orifice Uniform Deposit Impactor (MOUDI). The results revealed an optimal LLR-FEOT of 0.225 mm, which achieved similar output rates and residual volumes across various orientations. Additionally, a Dorifice exceeding 0.8 mm was necessary to ensure continuous nebulization, thereby yielding a residual volume of less than 4%. Using the FEOT instead of a traditional wick also significantly decreased the residual volume—a major advantage in delivering costly drugs. The consistently high efficiency of the MHVMN regardless of orientation demonstrates its suitability for administering aerosolized medication, especially to patients lying in bed.https://doi.org/10.4209/aaqr.2020.05.0203Vibrating mesh nebulizerOrientation-independentFlat end orifice tube |
| spellingShingle | Sheng-Hsiu Huang Chih-Wei Lin Wei-Ren Ke Yu-Mei Kuo Chih-Chieh Chen Development of an Orientation-independent Handheld Nebulizer Aerosol and Air Quality Research Vibrating mesh nebulizer Orientation-independent Flat end orifice tube |
| title | Development of an Orientation-independent Handheld Nebulizer |
| title_full | Development of an Orientation-independent Handheld Nebulizer |
| title_fullStr | Development of an Orientation-independent Handheld Nebulizer |
| title_full_unstemmed | Development of an Orientation-independent Handheld Nebulizer |
| title_short | Development of an Orientation-independent Handheld Nebulizer |
| title_sort | development of an orientation independent handheld nebulizer |
| topic | Vibrating mesh nebulizer Orientation-independent Flat end orifice tube |
| url | https://doi.org/10.4209/aaqr.2020.05.0203 |
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