The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles

The deficiency of chymase mast cell protease 4 exacerbates dextran sulfate sodium salt-induced colitis in mice and is associated with altered microbiota and metabolome profiles

IntroductionUlcerative colitis (UC) is a chronic gastrointestinal disease characterized by symptoms of abdominal pain and diarrhea. Chymase is a serine protease released by the mast cells and is highly expressed in patients with UC. However, its role in disease pathogenesis remains poorly understoo...

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Bibliographic Details
Main Authors: Zhiqiang Li, Xiaoyuan Kuang, Dashuang Mo, Magnus Åbrink, Ge Shan, Jin-ping Li, Can Yang, Yuexi Wang, Tao Shen, Weiwei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
ulcerative colitis
microbiota
chymase
exacerbation
metabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1481927/full
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