Synthesis, Characterization, and Biological Activity of a Novel <i>SA-g-p(AAc-co-AM)/ZnO NP</i> Hydrogel Composite

Synthesis, Characterization, and Biological Activity of a Novel <i>SA-g-p(AAc-co-AM)/ZnO NP</i> Hydrogel Composite

This research investigated the preparation and efficacy of a <i>SA-g-p(AAc-co-AM)/ZnO</i> hydrogel composite with enhanced biological activity. The hydrogel was synthesized using the sodium alginate biopolymer through the co-polymerization method. Our findings indicate that introducing z...

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Bibliographic Details
Main Authors: Aseel M. Aljeboree, Hadeel K. Albdairi, Mohammed Abed Jawad, Sarah A. Hamood, Firas H. Abdulrazzak, Ayad F. Alkaim
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Engineering Proceedings
Subjects:
hydrogel
sodium alginate
zinc oxide
antibacterial
Gram-positive
Gram-negative
Online Access:https://www.mdpi.com/2673-4591/59/1/192
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Summary:This research investigated the preparation and efficacy of a <i>SA-g-p(AAc-co-AM)/ZnO</i> hydrogel composite with enhanced biological activity. The hydrogel was synthesized using the sodium alginate biopolymer through the co-polymerization method. Our findings indicate that introducing zinc oxide nanoparticles to the hydrogel amplified its biological activity. The disc diffusion technique was applied to evaluate the antimicrobial properties against two Gram-positive bacteria isolates (<i>Staphylococcus aureus, Streptococcus epigenetics</i>) and two Gram-negative bacteria (<i>E.coli, Klebsiella</i> spp.). The antimicrobial activities of three surfaces—ZnO, <i>SA-g-p(AAc-co-AM)</i> hydrogel, and <i>SA-g-p(AAc-co-AM)/ZnO</i> hydrogel composite—were assessed. Characterization of these prepared surfaces was executed using FE-SEM and EDX. The results highlighted that the <i>ZnO NPs</i> exhibited minimal antibacterial activity against both types of bacteria. Conversely, the <i>SA-g-p(AAc-co-AM)/ZnO</i> hydrogel composite demonstrated heightened antibacterial effects against <i>Staphylococcus aureus</i> (30 mm) and <i>Streptococcus epigenetics</i> (25 mm). The Gram-negative bacteria, <i>E.coli</i> and <i>Klebsiella</i> spp., recorded inhibition zones of 13 mm and 12 mm, respectively. The <i>SA-g-p(AAc-co-AM)</i> hydrogel showed diminished antibacterial activity relative to the composite, attributed to the absence of zinc oxide. Overall, the isolated effect of zinc oxide nanoparticles indicated a minimal antibacterial influence on all Gram-positive and Gram-negative bacteria strains.
ISSN:2673-4591

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