Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence
Conclusions: These findings indicate that the SSL and AD pathways exhibit distinct miRNA expression dynamics during colorectal tumorigenesis, with the AD lineage showing a progressive increase in oncogenic miRNAs and the SSL series exhibiting selective downregulation or plateauing, particularly in i...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/grp/1010891 |
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| _version_ | 1850094195287523328 |
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| author | Takashi Murakami Hiroyuki Mitomi Naoki Tsugawa Yudai Otsuki Eiji Kamba Yuichiro Kadomatsu Takuo Hayashi Tsuyoshi Saito Tomoyoshi Shibuya Takashi Yao Akihito Nagahara |
| author_facet | Takashi Murakami Hiroyuki Mitomi Naoki Tsugawa Yudai Otsuki Eiji Kamba Yuichiro Kadomatsu Takuo Hayashi Tsuyoshi Saito Tomoyoshi Shibuya Takashi Yao Akihito Nagahara |
| author_sort | Takashi Murakami |
| collection | DOAJ |
| description | Conclusions: These findings indicate that the SSL and AD pathways exhibit distinct miRNA expression dynamics during colorectal tumorigenesis, with the AD lineage showing a progressive increase in oncogenic miRNAs and the SSL series exhibiting selective downregulation or plateauing, particularly in invasive lesions. The differential expression of miR-20a, miR-21, miR-93, and miR-181b was presumed to be related to (epi)genetic alterations among serrated neoplasia and AD–carcinoma routes. |
| format | Article |
| id | doaj-art-c15fe8fedef3430d9aed70a41b3e058b |
| institution | DOAJ |
| issn | 1687-630X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-c15fe8fedef3430d9aed70a41b3e058b2025-08-20T02:41:43ZengWileyGastroenterology Research and Practice1687-630X2025-01-01202510.1155/grp/1010891Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma SequenceTakashi Murakami0Hiroyuki Mitomi1Naoki Tsugawa2Yudai Otsuki3Eiji Kamba4Yuichiro Kadomatsu5Takuo Hayashi6Tsuyoshi Saito7Tomoyoshi Shibuya8Takashi Yao9Akihito Nagahara10Department of GastroenterologyDepartment of Human PathologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of Human PathologyDepartment of Human PathologyDepartment of Human PathologyDepartment of GastroenterologyDepartment of Human PathologyDepartment of GastroenterologyConclusions: These findings indicate that the SSL and AD pathways exhibit distinct miRNA expression dynamics during colorectal tumorigenesis, with the AD lineage showing a progressive increase in oncogenic miRNAs and the SSL series exhibiting selective downregulation or plateauing, particularly in invasive lesions. The differential expression of miR-20a, miR-21, miR-93, and miR-181b was presumed to be related to (epi)genetic alterations among serrated neoplasia and AD–carcinoma routes.http://dx.doi.org/10.1155/grp/1010891 |
| spellingShingle | Takashi Murakami Hiroyuki Mitomi Naoki Tsugawa Yudai Otsuki Eiji Kamba Yuichiro Kadomatsu Takuo Hayashi Tsuyoshi Saito Tomoyoshi Shibuya Takashi Yao Akihito Nagahara Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence Gastroenterology Research and Practice |
| title | Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence |
| title_full | Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence |
| title_fullStr | Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence |
| title_full_unstemmed | Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence |
| title_short | Differential Expression of MicroRNAs in the Colorectal Serrated Neoplasia Pathway and Adenoma–Carcinoma Sequence |
| title_sort | differential expression of micrornas in the colorectal serrated neoplasia pathway and adenoma carcinoma sequence |
| url | http://dx.doi.org/10.1155/grp/1010891 |
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