Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis
Introduction In the era of functional intraocular lens (IOL) implantation, it is crucial to investigate the influence of different capsulorhexis sizes (including the diameter of the capsulorhexis, area of the anterior capsule opening, anterior capsule coverage, centration and circularity of the caps...
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| Language: | English |
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BMJ Publishing Group
2024-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/12/e092002.full |
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| author | Yue Liu Yue Zhang Songhong Wang Tiexi Wu Xuejiao Qin |
| author_facet | Yue Liu Yue Zhang Songhong Wang Tiexi Wu Xuejiao Qin |
| author_sort | Yue Liu |
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| description | Introduction In the era of functional intraocular lens (IOL) implantation, it is crucial to investigate the influence of different capsulorhexis sizes (including the diameter of the capsulorhexis, area of the anterior capsule opening, anterior capsule coverage, centration and circularity of the capsulorhexis) on the postoperative outcomes (eg, visual acuity, capsule shrinkage, IOL stability and intraocular pressure) in patients undergoing cataract surgery. This is particularly important in patients with high myopia or diabetes mellitus. The proposed protocol aims to enhance the transparency of our research and offer references for future studies.Methods and analysis A comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, SinoMed, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform and China Science and Technology Journal Database is performed from inception to 4 July 2024. Data of individual participants will be collected from relevant clinical trials, both completed and ongoing. The collected data will be analysed using multilevel regression models to examine the association between capsulorhexis size and surgical outcomes. Potential demographic and clinical factors that may influence the results of cataract surgery, including postoperative visual acuity and IOL rotational stability, will also be explored. Any future modification to this protocol will include the date and rationale for the change.Ethics and dissemination Ethical approval is not required because the study does not involve individual patients. The study results are to be disseminated via professional journals as well as academic media.Trial registration number CRD42023459903. |
| format | Article |
| id | doaj-art-c15d20893095460b9004119610d28061 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-c15d20893095460b9004119610d280612025-01-14T17:55:12ZengBMJ Publishing GroupBMJ Open2044-60552024-12-01141210.1136/bmjopen-2024-092002Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysisYue Liu0Yue Zhang1Songhong Wang2Tiexi Wu3Xuejiao Qin41 Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, China1 Department of Oncology, People`s Liberation Army The General Hospital of Western Theater Command, Chengdu, Sichuan, China1 Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, China1 Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, China1 Department of Ophthalmology, The Second Hospital of Shandong University, Jinan, Shandong, ChinaIntroduction In the era of functional intraocular lens (IOL) implantation, it is crucial to investigate the influence of different capsulorhexis sizes (including the diameter of the capsulorhexis, area of the anterior capsule opening, anterior capsule coverage, centration and circularity of the capsulorhexis) on the postoperative outcomes (eg, visual acuity, capsule shrinkage, IOL stability and intraocular pressure) in patients undergoing cataract surgery. This is particularly important in patients with high myopia or diabetes mellitus. The proposed protocol aims to enhance the transparency of our research and offer references for future studies.Methods and analysis A comprehensive search of PubMed, Embase, Cochrane Library, Web of Science, SinoMed, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform and China Science and Technology Journal Database is performed from inception to 4 July 2024. Data of individual participants will be collected from relevant clinical trials, both completed and ongoing. The collected data will be analysed using multilevel regression models to examine the association between capsulorhexis size and surgical outcomes. Potential demographic and clinical factors that may influence the results of cataract surgery, including postoperative visual acuity and IOL rotational stability, will also be explored. Any future modification to this protocol will include the date and rationale for the change.Ethics and dissemination Ethical approval is not required because the study does not involve individual patients. The study results are to be disseminated via professional journals as well as academic media.Trial registration number CRD42023459903.https://bmjopen.bmj.com/content/14/12/e092002.full |
| spellingShingle | Yue Liu Yue Zhang Songhong Wang Tiexi Wu Xuejiao Qin Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis BMJ Open |
| title | Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis |
| title_full | Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis |
| title_fullStr | Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis |
| title_full_unstemmed | Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis |
| title_short | Effect of size of capsulorhexis on the outcome of cataract surgery: a protocol for systematic review and individual participant data meta-analysis |
| title_sort | effect of size of capsulorhexis on the outcome of cataract surgery a protocol for systematic review and individual participant data meta analysis |
| url | https://bmjopen.bmj.com/content/14/12/e092002.full |
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