Association of Inflammatory Markers with the Severity of COVID-19
Introduction: Corona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent corona virus. It was first recognized in Wuhan, China, in December 2019, and was reported to cause severe acute respiratory syndrome. Accumulating evidence has suggested that inflammatory responses play a cr...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-07-01
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| Series: | CHRISMED Journal of Health and Research |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/cjhr.cjhr_87_24 |
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| Summary: | Introduction:
Corona virus disease 2019 (COVID-19) is caused by SARS-CoV-2, a newly emergent corona virus. It was first recognized in Wuhan, China, in December 2019, and was reported to cause severe acute respiratory syndrome. Accumulating evidence has suggested that inflammatory responses play a critical role in the progression of COVID-19. Inflammatory responses triggered by rapid viral replication of SARS-CoV-2 and cellular destruction can recruit macrophages and monocytes and induce the release of cytokines. Inflammatory markers such as serum Ferritin, C-reactive protein (CRP) and Interleukin-6 (IL-6), D-dimer have been reported to be significantly associated with the high risks of the development of severe Covid19.
Objective:
To find out association of inflammatory markers with the severity of covid-19. Find out association of inflammatory markers with the severity of covid-19.To find out which inflammatory marker is associated more with disease severity.
Materials and Methods:
The Study was conducted in In-patient Department of Internal Medicine, Respiratory medicine and intensive care unit of Max Super Speciality hospital complex ,Saket,New Delhi. It was a hospital-based, prospective observational, cross sectional study. Patients admitted with COVID-19 in Max Super Specialty Hospital Complex, Saket during this study period, fulfilling the inclusion and exclusion criteria enrolled, Informed consent has been taken from all of them. This study approved by Institutional Ethical committee. The data entered in MS EXCEL spreadsheet and analysis have been done using Statistical Package for Social Sciences (SPSS) version 25.0.P value <0.05 was considered as statistically significant.
Results:
In the study, we have analyzed data of 425 patients, in which 59% of the patients were male while 40 % were female. Mean age of patients was 57 years. Various markers were taken under study viz;IL-6,with mean and SD as 39.65 pg/ml and 41.12 pg/ml, ferritin, D-dimer with mean 290.56 ng/ml and 421.16 ng/ml respectively. SpO2% level of patients has been measured with mean 93.28% and SD 5.01%. Pearson correlation coefficient were calculated between various markers and Spo2 (%) level of patients. Markers showing negative correlation viz; IL-6 (r = -0.369), CRP (r = -0.460). Mean level of all markers are more in severe group, also showing significant difference from non-severe group except D-dimer.
Conclusion:
It is feasible that inflammatory markers may still be effective and favorable in future clinical decision criteria. Measurement of inflammatory markers might aid clinicians to guide and evaluate COVID-19 severity, prognosis of disease and potential therapeutic targets. |
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| ISSN: | 2348-3334 2348-506X |