Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe
Efficient delivery of photons to visceral organs is critical for the treatment of deep‐seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spati...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-02-01
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| Series: | Small Science |
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| Online Access: | https://doi.org/10.1002/smsc.202400450 |
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| author | Fangzhou Jin Zhiyuan Xu Wei Wang Zhongyuan Cheng Yang Wu Zesen Li Enlai Song Xu Yue Yong Kang Zhang Wei Li Youzhen Feng Donglin Cao Dongmei Zhang Minfeng Chen Xiangran Cai Yang Ran Bai‐Ou Guan |
| author_facet | Fangzhou Jin Zhiyuan Xu Wei Wang Zhongyuan Cheng Yang Wu Zesen Li Enlai Song Xu Yue Yong Kang Zhang Wei Li Youzhen Feng Donglin Cao Dongmei Zhang Minfeng Chen Xiangran Cai Yang Ran Bai‐Ou Guan |
| author_sort | Fangzhou Jin |
| collection | DOAJ |
| description | Efficient delivery of photons to visceral organs is critical for the treatment of deep‐seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, an integrated fiber‐optic theranostic (iFOT) probe is developed that merges tumor microenvironment sensing and photothermal therapy by functionalizing the fiber with graphene/gold nanostar hybrid materials and hypoxic‐responsive fluorophores. The iFOT probe can quickly detect the hypoxia of xenograft tumors of mice with high sensitivity. The tumors can be photothermally killed on‐site through the same fiber probe tightly followed by detection, which presents a high cure rate. More importantly, the iFOT is highly adaptable to the conventional medical imaging and endoscopic techniques, which facilitates the imaging‐assisted navigation and manipulation by use of the interventional trocar. The proposed strategy can be used as an effective endoscopic and interventional tool for tackling deep‐situated tumor and may open a revolutionized pathway to bridge separate diagnosis and therapy process in the current stage. |
| format | Article |
| id | doaj-art-c1574bb6bb3b44a2af7058cacbe2eaab |
| institution | OA Journals |
| issn | 2688-4046 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Science |
| spelling | doaj-art-c1574bb6bb3b44a2af7058cacbe2eaab2025-08-20T01:53:10ZengWiley-VCHSmall Science2688-40462025-02-0152n/an/a10.1002/smsc.202400450Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic ProbeFangzhou Jin0Zhiyuan Xu1Wei Wang2Zhongyuan Cheng3Yang Wu4Zesen Li5Enlai Song6Xu Yue7Yong Kang Zhang8Wei Li9Youzhen Feng10Donglin Cao11Dongmei Zhang12Minfeng Chen13Xiangran Cai14Yang Ran15Bai‐Ou Guan16Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaDepartment of Laboratory Medicine The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou 510317 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaMedical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaMedical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaDepartment of Laboratory Medicine The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou 510317 ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Guangzhou 510632 ChinaState Key Laboratory of Bioactive Molecules and Druggability Assessment Jinan University Guangzhou 510632 ChinaMedical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou 510630 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications, Institute of Photonics Technology Jinan University Guangzhou 510632 ChinaEfficient delivery of photons to visceral organs is critical for the treatment of deep‐seated tumors taking advantage of photo theranostics. Optical fiber can be regarded as a direct and facile photon pathway for targeting tumor lesion. However, current fiber theranostic strategies rely on the spatially separated optical fibers to realize diagnosis and therapy independently, resulting in low compactness, poor continuity of medical process, and incompatibility with current medical technologies. Herein, an integrated fiber‐optic theranostic (iFOT) probe is developed that merges tumor microenvironment sensing and photothermal therapy by functionalizing the fiber with graphene/gold nanostar hybrid materials and hypoxic‐responsive fluorophores. The iFOT probe can quickly detect the hypoxia of xenograft tumors of mice with high sensitivity. The tumors can be photothermally killed on‐site through the same fiber probe tightly followed by detection, which presents a high cure rate. More importantly, the iFOT is highly adaptable to the conventional medical imaging and endoscopic techniques, which facilitates the imaging‐assisted navigation and manipulation by use of the interventional trocar. The proposed strategy can be used as an effective endoscopic and interventional tool for tackling deep‐situated tumor and may open a revolutionized pathway to bridge separate diagnosis and therapy process in the current stage.https://doi.org/10.1002/smsc.202400450imaging‐assisted navigationmicroenvironment sensingoptical fibersphotothermal therapytumor theranostics |
| spellingShingle | Fangzhou Jin Zhiyuan Xu Wei Wang Zhongyuan Cheng Yang Wu Zesen Li Enlai Song Xu Yue Yong Kang Zhang Wei Li Youzhen Feng Donglin Cao Dongmei Zhang Minfeng Chen Xiangran Cai Yang Ran Bai‐Ou Guan Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe Small Science imaging‐assisted navigation microenvironment sensing optical fibers photothermal therapy tumor theranostics |
| title | Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe |
| title_full | Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe |
| title_fullStr | Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe |
| title_full_unstemmed | Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe |
| title_short | Integrating Tumor Hypoxic Sensing and Photothermal Therapy Using a Miniaturized Fiber‐Optic Theranostic Probe |
| title_sort | integrating tumor hypoxic sensing and photothermal therapy using a miniaturized fiber optic theranostic probe |
| topic | imaging‐assisted navigation microenvironment sensing optical fibers photothermal therapy tumor theranostics |
| url | https://doi.org/10.1002/smsc.202400450 |
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