Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics
Abstract Sepsis is a life-threatening multiple organ dysfunction resulting from a dysregulated host response to infection, and patients with sepsis always exhibit a state of immune disorder characterized by both overwhelming inflammation and immunosuppression. The aging of immune system, namely “imm...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-05-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-025-07714-w |
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| _version_ | 1850154584165580800 |
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| author | Yanghanzhao Wang Hao Zhang Changhong Miao |
| author_facet | Yanghanzhao Wang Hao Zhang Changhong Miao |
| author_sort | Yanghanzhao Wang |
| collection | DOAJ |
| description | Abstract Sepsis is a life-threatening multiple organ dysfunction resulting from a dysregulated host response to infection, and patients with sepsis always exhibit a state of immune disorder characterized by both overwhelming inflammation and immunosuppression. The aging of immune system, namely “immunosenescence”, has been reported to be correlated with high morbidity and mortality in elderly patients with sepsis. Initially, immunosenescence was considered as a range of age-related alterations in the immune system. However, increasing evidence has proven that persistent inflammation or even a short-term inflammatory challenge during sepsis could trigger accelerated aging of immune cells, which might further exacerbate inflammatory cytokine storm and promote the shift towards immunosuppression. Thus, premature immunosenescence is found in young sepsis individuals, which further aggravates immune disorders and induces the progression of sepsis. Furthermore, in old sepsis patients, the synergistic effects of both sepsis and aging may cause immunosenescence-associated alterations more significantly, resulting in more severe immune dysfunction and a worse prognosis. Therefore, it is necessary to explore the potential therapeutic strategies targeting immunosenescence during sepsis. |
| format | Article |
| id | doaj-art-c154c1f65c9e4175bf4c6a5a5e3d8d72 |
| institution | OA Journals |
| issn | 2041-4889 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj-art-c154c1f65c9e4175bf4c6a5a5e3d8d722025-08-20T02:25:17ZengNature Publishing GroupCell Death and Disease2041-48892025-05-0116111910.1038/s41419-025-07714-wUnraveling immunosenescence in sepsis: from cellular mechanisms to therapeuticsYanghanzhao Wang0Hao Zhang1Changhong Miao2Department of Anesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anesthesiology, Zhongshan Hospital, Fudan UniversityDepartment of Anesthesiology, Zhongshan Hospital, Fudan UniversityAbstract Sepsis is a life-threatening multiple organ dysfunction resulting from a dysregulated host response to infection, and patients with sepsis always exhibit a state of immune disorder characterized by both overwhelming inflammation and immunosuppression. The aging of immune system, namely “immunosenescence”, has been reported to be correlated with high morbidity and mortality in elderly patients with sepsis. Initially, immunosenescence was considered as a range of age-related alterations in the immune system. However, increasing evidence has proven that persistent inflammation or even a short-term inflammatory challenge during sepsis could trigger accelerated aging of immune cells, which might further exacerbate inflammatory cytokine storm and promote the shift towards immunosuppression. Thus, premature immunosenescence is found in young sepsis individuals, which further aggravates immune disorders and induces the progression of sepsis. Furthermore, in old sepsis patients, the synergistic effects of both sepsis and aging may cause immunosenescence-associated alterations more significantly, resulting in more severe immune dysfunction and a worse prognosis. Therefore, it is necessary to explore the potential therapeutic strategies targeting immunosenescence during sepsis.https://doi.org/10.1038/s41419-025-07714-w |
| spellingShingle | Yanghanzhao Wang Hao Zhang Changhong Miao Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics Cell Death and Disease |
| title | Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics |
| title_full | Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics |
| title_fullStr | Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics |
| title_full_unstemmed | Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics |
| title_short | Unraveling immunosenescence in sepsis: from cellular mechanisms to therapeutics |
| title_sort | unraveling immunosenescence in sepsis from cellular mechanisms to therapeutics |
| url | https://doi.org/10.1038/s41419-025-07714-w |
| work_keys_str_mv | AT yanghanzhaowang unravelingimmunosenescenceinsepsisfromcellularmechanismstotherapeutics AT haozhang unravelingimmunosenescenceinsepsisfromcellularmechanismstotherapeutics AT changhongmiao unravelingimmunosenescenceinsepsisfromcellularmechanismstotherapeutics |