Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria

Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria

Abstract In patients with hepatocellular carcinoma (HCC) meeting the Milan criteria, liver transplantation (LT) is an effective therapy. This study aims to define the survival-related molecular biological features helping precisely identifying the patients with HCC beyond the Milan criteria who have...

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Main Authors: Sunbin Ling, Jiongjie Yu, Qifan Zhan, Mingwei Gao, Peng Liu, Yongfeng Wu, Lincheng Zhang, Qiaonan Shan, Huan Liu, Jiapei Wang, Shuqi Cai, Wei Zhou, Qingyang Que, Shuo Wang, Jiachen Hong, Jianan Xiang, Shengjun Xu, Jimin Liu, Xiaojun Peng, Nan Wang, Weixin Wang, Haiyang Xie, Jinzhen Cai, Liming Wang, Shusen Zheng, Xiao Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59745-8
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https://doi.org/10.1038/s41467-025-59745-8

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