Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease
The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms includi...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Biochemistry Research International |
| Online Access: | http://dx.doi.org/10.1155/2012/789083 |
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| _version_ | 1832564850563219456 |
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| author | Hiromi Fujioka Yusuke Dairyo Kei-ichiro Yasunaga Kazuo Emoto |
| author_facet | Hiromi Fujioka Yusuke Dairyo Kei-ichiro Yasunaga Kazuo Emoto |
| author_sort | Hiromi Fujioka |
| collection | DOAJ |
| description | The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease. |
| format | Article |
| id | doaj-art-c1410f92c03a4fcbbba9108f0015208c |
| institution | Kabale University |
| issn | 2090-2247 2090-2255 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biochemistry Research International |
| spelling | doaj-art-c1410f92c03a4fcbbba9108f0015208c2025-02-03T01:10:09ZengWileyBiochemistry Research International2090-22472090-22552012-01-01201210.1155/2012/789083789083Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and DiseaseHiromi Fujioka0Yusuke Dairyo1Kei-ichiro Yasunaga2Kazuo Emoto3Department of Cell Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, JapanDepartment of Cell Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, JapanDepartment of Cell Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, JapanDepartment of Cell Biology, Osaka Bioscience Institute, 6-2-4 Furuedai, Suita, Osaka 565-0874, JapanThe brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease.http://dx.doi.org/10.1155/2012/789083 |
| spellingShingle | Hiromi Fujioka Yusuke Dairyo Kei-ichiro Yasunaga Kazuo Emoto Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease Biochemistry Research International |
| title | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
| title_full | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
| title_fullStr | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
| title_full_unstemmed | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
| title_short | Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease |
| title_sort | neural functions of matrix metalloproteinases plasticity neurogenesis and disease |
| url | http://dx.doi.org/10.1155/2012/789083 |
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