Neural Functions of Matrix Metalloproteinases: Plasticity, Neurogenesis, and Disease

The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms includi...

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Bibliographic Details
Main Authors: Hiromi Fujioka, Yusuke Dairyo, Kei-ichiro Yasunaga, Kazuo Emoto
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Biochemistry Research International
Online Access:http://dx.doi.org/10.1155/2012/789083
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Summary:The brain changes in response to experience and altered environment. To do that, the nervous system often remodels the structures of neuronal circuits. This structural plasticity of the neuronal circuits appears to be controlled not only by intrinsic factors, but also by extrinsic mechanisms including modification of the extracellular matrix. Recent studies employing a range of animal models implicate that matrix metalloproteinases regulate multiple aspects of the neuronal development and remodeling in the brain. This paper aims to summarize recent advances of our knowledge on the neuronal functions of matrix metalloproteinases and discuss how they might relate in neuronal disease.
ISSN:2090-2247
2090-2255