Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D
Abstract Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care. Recombinant proteins (RP), recombin...
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2025-07-01
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| Online Access: | https://doi.org/10.1007/s00726-025-03465-2 |
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| author | Sandra Rodrigues Xavier Isabelle Caroline dos Santos Barcelos Isadora Braga Gandra Sabrina Paula Pereira Anna Julia Ribeiro Kamila Alves Silva Carlos Ananias Aparecido Resende Lucas da Silva Lopes Rafaela Camargo Rodrigues Machado Leonardo Maciel Santos Silva Líria Souza Silva Lívia Corrêa Ferreira Luiz Fellype Alves de Souza Rutilene Barbosa Souza Ana Maísa Passos-Silva Mariana Campos da Paz Miguel Angel Chávez Fumagalli Eduardo Antônio Ferraz Coelho Rodolfo Cordeiro Giunchetti Juliana Martins Machado Ana Alice Maia Gonçalves Soraya dos Santos Pereira Daniel Archimedes da Matta Deusilene Souza Vieira Alexsandro Sobreira Galdino |
| author_facet | Sandra Rodrigues Xavier Isabelle Caroline dos Santos Barcelos Isadora Braga Gandra Sabrina Paula Pereira Anna Julia Ribeiro Kamila Alves Silva Carlos Ananias Aparecido Resende Lucas da Silva Lopes Rafaela Camargo Rodrigues Machado Leonardo Maciel Santos Silva Líria Souza Silva Lívia Corrêa Ferreira Luiz Fellype Alves de Souza Rutilene Barbosa Souza Ana Maísa Passos-Silva Mariana Campos da Paz Miguel Angel Chávez Fumagalli Eduardo Antônio Ferraz Coelho Rodolfo Cordeiro Giunchetti Juliana Martins Machado Ana Alice Maia Gonçalves Soraya dos Santos Pereira Daniel Archimedes da Matta Deusilene Souza Vieira Alexsandro Sobreira Galdino |
| author_sort | Sandra Rodrigues Xavier |
| collection | DOAJ |
| description | Abstract Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care. Recombinant proteins (RP), recombinant multiepitope proteins (RMP), and synthetic peptides have been extensively reported as tools for efficient immunodiagnosis of several diseases. This review aimed to discuss the use of these antigens for the immunodiagnosis of HD. To this end, a bibliographic study was conducted in the PubMed database by searching the primary (“Hepatitis D” and “Hepatitis Delta”), secondary (“Detection”, “Diagno*”, “Diagnosis”, “Immunodiagnosis”, and “Serodiagnosis”), and tertiary (“Chimera”, “Epitope”, “Peptide”; “Protein” and “Recombinant”) descriptors, including papers published up to January 2025. Review articles and case reports were excluded. Only nine articles (five for RP, three for synthetic peptides, and one for RMP) met the inclusion criteria, revealing that there are very few studies on this subject, particularly when compared to the advances made in the diagnosis of hepatitis A, B, and C. Despite the scarcity of articles published in the literature, six of the nine analyzed studies corroborate the potential of these antigens to effectively replace traditional diagnostic methods, including development of rapid tests. These data highlight the need for further studies to assess the potential of RP, RMP, and synthetic peptides for immunodiagnosis of HD, aiming to increase the accuracy of diagnosis, as well as improve monitoring and prevention. |
| format | Article |
| id | doaj-art-c13bba92de6a480bb958453192b248bf |
| institution | DOAJ |
| issn | 1438-2199 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Amino Acids |
| spelling | doaj-art-c13bba92de6a480bb958453192b248bf2025-08-20T03:03:33ZengSpringerAmino Acids1438-21992025-07-0157112010.1007/s00726-025-03465-2Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis DSandra Rodrigues Xavier0Isabelle Caroline dos Santos Barcelos1Isadora Braga Gandra2Sabrina Paula Pereira3Anna Julia Ribeiro4Kamila Alves Silva5Carlos Ananias Aparecido Resende6Lucas da Silva Lopes7Rafaela Camargo Rodrigues Machado8Leonardo Maciel Santos Silva9Líria Souza Silva10Lívia Corrêa Ferreira11Luiz Fellype Alves de Souza12Rutilene Barbosa Souza13Ana Maísa Passos-Silva14Mariana Campos da Paz15Miguel Angel Chávez Fumagalli16Eduardo Antônio Ferraz Coelho17Rodolfo Cordeiro Giunchetti18Juliana Martins Machado19Ana Alice Maia Gonçalves20Soraya dos Santos Pereira21Daniel Archimedes da Matta22Deusilene Souza Vieira23Alexsandro Sobreira Galdino24Laboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiCentro de Infectologia Charles Merieux & Laboratório Rodolphe Merieux (FUNDHACRE)Centro de Infectologia Charles Merieux & Laboratório Rodolphe Merieux (FUNDHACRE)Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia-FIOCRUZ/ROLaboratório de Bioativos e Nanobiotecnologia, Universidade Federal de São João Del-ReiComputational Biology and Chemistry Research Group, Vicerrectorado de Investigación, Universidad Católica de Santa MaríaPrograma de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas GeraisLaboratório de Biologia das Interações Celulares, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas GeraisLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiLaboratório de Engenharia de Anticorpos, Fundação Oswaldo Cruz Rondônia-FIOCRUZ/ROCentro de Infectologia Charles Merieux & Laboratório Rodolphe Merieux (FUNDHACRE)Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia-FIOCRUZ/ROLaboratório de Biotecnologia de Microrganismos, Universidade Federal de São João Del-ReiAbstract Designing innovative, accurate, universal, and accessible diagnostic tests is mandatory to improve screening, prevention, and management of hepatitis D (HD), especially in endemic areas with poor infrastructure and restricted access to public health care. Recombinant proteins (RP), recombinant multiepitope proteins (RMP), and synthetic peptides have been extensively reported as tools for efficient immunodiagnosis of several diseases. This review aimed to discuss the use of these antigens for the immunodiagnosis of HD. To this end, a bibliographic study was conducted in the PubMed database by searching the primary (“Hepatitis D” and “Hepatitis Delta”), secondary (“Detection”, “Diagno*”, “Diagnosis”, “Immunodiagnosis”, and “Serodiagnosis”), and tertiary (“Chimera”, “Epitope”, “Peptide”; “Protein” and “Recombinant”) descriptors, including papers published up to January 2025. Review articles and case reports were excluded. Only nine articles (five for RP, three for synthetic peptides, and one for RMP) met the inclusion criteria, revealing that there are very few studies on this subject, particularly when compared to the advances made in the diagnosis of hepatitis A, B, and C. Despite the scarcity of articles published in the literature, six of the nine analyzed studies corroborate the potential of these antigens to effectively replace traditional diagnostic methods, including development of rapid tests. These data highlight the need for further studies to assess the potential of RP, RMP, and synthetic peptides for immunodiagnosis of HD, aiming to increase the accuracy of diagnosis, as well as improve monitoring and prevention.https://doi.org/10.1007/s00726-025-03465-2Hepatitis deltaImmunodiagnosisSerodiagnosisRecombinant antigensSynthetic peptides |
| spellingShingle | Sandra Rodrigues Xavier Isabelle Caroline dos Santos Barcelos Isadora Braga Gandra Sabrina Paula Pereira Anna Julia Ribeiro Kamila Alves Silva Carlos Ananias Aparecido Resende Lucas da Silva Lopes Rafaela Camargo Rodrigues Machado Leonardo Maciel Santos Silva Líria Souza Silva Lívia Corrêa Ferreira Luiz Fellype Alves de Souza Rutilene Barbosa Souza Ana Maísa Passos-Silva Mariana Campos da Paz Miguel Angel Chávez Fumagalli Eduardo Antônio Ferraz Coelho Rodolfo Cordeiro Giunchetti Juliana Martins Machado Ana Alice Maia Gonçalves Soraya dos Santos Pereira Daniel Archimedes da Matta Deusilene Souza Vieira Alexsandro Sobreira Galdino Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D Amino Acids Hepatitis delta Immunodiagnosis Serodiagnosis Recombinant antigens Synthetic peptides |
| title | Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D |
| title_full | Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D |
| title_fullStr | Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D |
| title_full_unstemmed | Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D |
| title_short | Proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis D |
| title_sort | proteins and peptides as antigen candidates for the immunodiagnosis of hepatitis d |
| topic | Hepatitis delta Immunodiagnosis Serodiagnosis Recombinant antigens Synthetic peptides |
| url | https://doi.org/10.1007/s00726-025-03465-2 |
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