Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers
Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identi...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2009-09-01
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| Series: | Сахарный диабет |
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| Online Access: | https://www.dia-endojournals.ru/jour/article/view/5449 |
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| author | Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova |
| author_facet | Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova |
| author_sort | Olga Nikolavna Ivanova |
| collection | DOAJ |
| description | Aim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identified by multiprimer allele-specific PCR. Association with DM1 was evaluated from the OR-odds ratio. Calculations were made usingStatSoft and STATISTICA 6 programs. Results. The occurrence of ?classical? highly predisposing haplotypes in the studied Udmurtian population proved significantly lower than in otherCaucasoid populations (DRB1*04-DQA1*0301-DQB1*0302 - 2,6 vs 8-16% and DRB1*17(03)-DQA*0501-DQB1*0201 - 3,6 vs 6-12,9%)trans-Encoded DQ heterodimers (DQA1*0301-DQB1*0201 and DQA1*0301-DQB1*0302) were shown to play the key role in determining the riskof DM1. They were found in 62,1% of the patients compared with 10,3% of control subjects (OR=14,2; pc=6Ч10-5). Conclusion. Positive DQA1*0301-DQB1*0302 or/and *0201 genotype is the most sensitive predictor of DM1 in the studied Udmurtian population. |
| format | Article |
| id | doaj-art-c1354ef0d7644f4ea194a46c7a1b43bb |
| institution | Kabale University |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2009-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-c1354ef0d7644f4ea194a46c7a1b43bb2025-08-20T03:48:28ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782009-09-01123333610.14341/2072-0351-54495407Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimersOlga Nikolavna Ivanova0Sergey Alexandrovich Prokof'ev1Yana Stanislavovna Zvereva2Tatiana Viktorovna Kovalenko3Andrey Vladimirovich Blinov4Valentina Alexandrovna Peterkova5Endocrinological Research Centre, MoscowEndocrinological Research Centre, MoscowEndocrinological Research Centre, MoscowIzhevsk State Medical Academy, IzhevskIzhevsk State Medical Academy, IzhevskEndocrinological Research Centre, MoscowAim. To analyse association of class II HLA genotype (DRB1, DQA1, DQB1) with type 1 diabetes mellitus (DM1) in an Udmurtian population. Materials and methods. The case-control method was applied in the study involving 29 children with DM1 and 97 age-matched healthy subjects. HLAalleles were identified by multiprimer allele-specific PCR. Association with DM1 was evaluated from the OR-odds ratio. Calculations were made usingStatSoft and STATISTICA 6 programs. Results. The occurrence of ?classical? highly predisposing haplotypes in the studied Udmurtian population proved significantly lower than in otherCaucasoid populations (DRB1*04-DQA1*0301-DQB1*0302 - 2,6 vs 8-16% and DRB1*17(03)-DQA*0501-DQB1*0201 - 3,6 vs 6-12,9%)trans-Encoded DQ heterodimers (DQA1*0301-DQB1*0201 and DQA1*0301-DQB1*0302) were shown to play the key role in determining the riskof DM1. They were found in 62,1% of the patients compared with 10,3% of control subjects (OR=14,2; pc=6Ч10-5). Conclusion. Positive DQA1*0301-DQB1*0302 or/and *0201 genotype is the most sensitive predictor of DM1 in the studied Udmurtian population.https://www.dia-endojournals.ru/jour/article/view/5449dqa1type 1 diabetes mellitusclass ii hla drb1dqa1dqb1 genesrole of dq heterodimersudmurtian population |
| spellingShingle | Olga Nikolavna Ivanova Sergey Alexandrovich Prokof'ev Yana Stanislavovna Zvereva Tatiana Viktorovna Kovalenko Andrey Vladimirovich Blinov Valentina Alexandrovna Peterkova Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers Сахарный диабет dqa1 type 1 diabetes mellitus class ii hla drb1 dqa1 dqb1 genes role of dq heterodimers udmurtian population |
| title | Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers |
| title_full | Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers |
| title_fullStr | Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers |
| title_full_unstemmed | Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers |
| title_short | Class II HLA diabetogenic markers in an Udmurtian population: genotype dependence, the role of DQ trans-heterodimers |
| title_sort | class ii hla diabetogenic markers in an udmurtian population genotype dependence the role of dq trans heterodimers |
| topic | dqa1 type 1 diabetes mellitus class ii hla drb1 dqa1 dqb1 genes role of dq heterodimers udmurtian population |
| url | https://www.dia-endojournals.ru/jour/article/view/5449 |
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