Hippo/YAP signaling’s multifaceted crosstalk in cancer
The Hippo/yes-associated protein (YAP) signaling is an evolutionarily conserved regulator in organ size control, which plays pivotal roles in cell proliferation, differentiation, apoptosis, and tissue regeneration. In cancer, dysregulation of Hippo/YAP signaling is typically recognized as one of the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1595362/full |
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| author | Jie Zhang Haipeng Wu Haipeng Wu Xinxin Ren Zhuoshi Chen Siyu Ye Shuchang Chen Jie Fang Qirou Wu Tiejun Zhao Tiejun Zhao |
| author_facet | Jie Zhang Haipeng Wu Haipeng Wu Xinxin Ren Zhuoshi Chen Siyu Ye Shuchang Chen Jie Fang Qirou Wu Tiejun Zhao Tiejun Zhao |
| author_sort | Jie Zhang |
| collection | DOAJ |
| description | The Hippo/yes-associated protein (YAP) signaling is an evolutionarily conserved regulator in organ size control, which plays pivotal roles in cell proliferation, differentiation, apoptosis, and tissue regeneration. In cancer, dysregulation of Hippo/YAP signaling is typically recognized as one of the crucial drivers in tumorigenesis. However, beyond its canonical transcriptional targets, Hippo/YAP signaling engages in extensive crosstalk with multiple pathways to form an intricate regulatory network, thereby giving rise to its content-dependent influence on tumor initiation, progression and metastasis. This review focuses on the molecular mechanisms underlying the interplay between Hippo/YAP and pivotal signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), wingless-type (Wnt)/β-catenin signaling pathway, transforming growth factor-beta (TGF-β), Hedgehog, Notch and other signaling pathways, as well as their implications in cancer biology. Ultimately, exploiting these mechanisms may represent promising therapeutic strategies for cancer. |
| format | Article |
| id | doaj-art-c130a1d9fb7643bc9e6ce873fdce022a |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-c130a1d9fb7643bc9e6ce873fdce022a2025-08-20T03:28:43ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-07-011310.3389/fcell.2025.15953621595362Hippo/YAP signaling’s multifaceted crosstalk in cancerJie Zhang0Haipeng Wu1Haipeng Wu2Xinxin Ren3Zhuoshi Chen4Siyu Ye5Shuchang Chen6Jie Fang7Qirou Wu8Tiejun Zhao9Tiejun Zhao10Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaCollege of Pharmaceutical Science, Zhejiang University, Hangzhou, ChinaCollege of Life Sciences, Zhejiang Normal University, Jinhua, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaCollege of Life Sciences, Zhejiang Normal University, Jinhua, ChinaThe Hippo/yes-associated protein (YAP) signaling is an evolutionarily conserved regulator in organ size control, which plays pivotal roles in cell proliferation, differentiation, apoptosis, and tissue regeneration. In cancer, dysregulation of Hippo/YAP signaling is typically recognized as one of the crucial drivers in tumorigenesis. However, beyond its canonical transcriptional targets, Hippo/YAP signaling engages in extensive crosstalk with multiple pathways to form an intricate regulatory network, thereby giving rise to its content-dependent influence on tumor initiation, progression and metastasis. This review focuses on the molecular mechanisms underlying the interplay between Hippo/YAP and pivotal signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), wingless-type (Wnt)/β-catenin signaling pathway, transforming growth factor-beta (TGF-β), Hedgehog, Notch and other signaling pathways, as well as their implications in cancer biology. Ultimately, exploiting these mechanisms may represent promising therapeutic strategies for cancer.https://www.frontiersin.org/articles/10.3389/fcell.2025.1595362/fullHippo/YAP signalingsignaling pathwaycrosstalkcancertherapeutic target |
| spellingShingle | Jie Zhang Haipeng Wu Haipeng Wu Xinxin Ren Zhuoshi Chen Siyu Ye Shuchang Chen Jie Fang Qirou Wu Tiejun Zhao Tiejun Zhao Hippo/YAP signaling’s multifaceted crosstalk in cancer Frontiers in Cell and Developmental Biology Hippo/YAP signaling signaling pathway crosstalk cancer therapeutic target |
| title | Hippo/YAP signaling’s multifaceted crosstalk in cancer |
| title_full | Hippo/YAP signaling’s multifaceted crosstalk in cancer |
| title_fullStr | Hippo/YAP signaling’s multifaceted crosstalk in cancer |
| title_full_unstemmed | Hippo/YAP signaling’s multifaceted crosstalk in cancer |
| title_short | Hippo/YAP signaling’s multifaceted crosstalk in cancer |
| title_sort | hippo yap signaling s multifaceted crosstalk in cancer |
| topic | Hippo/YAP signaling signaling pathway crosstalk cancer therapeutic target |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1595362/full |
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