Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes
Pre-diabetes is characterized by elevated blood sugar levels that are not yet high enough for a Type 2 diabetes diagnosis. Type 2 diabetes results from insufficient insulin production or cellular resistance to insulin. Adiponectin, secreted by adipose tissue, regulates glucose metabolism and energy...
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| Format: | Article |
| Language: | English |
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Bogor Agricultural University
2025-03-01
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| Series: | Hayati Journal of Biosciences |
| Online Access: | https://journal.ipb.ac.id/index.php/hayati/article/view/59539 |
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| author | Abdullah Abdulsattar Raeef Mohammed Hashim Mohammed Jwan Najm Abdullah |
| author_facet | Abdullah Abdulsattar Raeef Mohammed Hashim Mohammed Jwan Najm Abdullah |
| author_sort | Abdullah Abdulsattar Raeef |
| collection | DOAJ |
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Pre-diabetes is characterized by elevated blood sugar levels that are not yet high enough for a Type 2 diabetes diagnosis. Type 2 diabetes results from insufficient insulin production or cellular resistance to insulin. Adiponectin, secreted by adipose tissue, regulates glucose metabolism and energy balance, while nesfatin-1, derived from NUCB2, influences appetite and energy homeostasis. This case-control study at Al-Ramadi Teaching Hospital included 80 participants with diabetes mellitus (DM) or early-stage DM and 40 healthy controls. Demographic data, including age, Body mass index (BMI), and disease duration, were collected. Laboratory tests measured fasting blood glucose (FBG), Glycated hemoglobin (HbA1c%), insulin, adiponectin, and nesfatin-1 levels. Statistical analyses, including ANOVA, Pearson’s correlation, and AUC analysis, assessed relationships and diagnostic accuracy. Results showed significantly higher levels of FBG, HbA1c, insulin resistance, and nesfatin-1 in early diabetes and DM type 2 cases compared to healthy controls. Nesfatin-1 concentrations were also notably higher in early diabetes compared to other groups. Adiponectin levels did not significantly differ between early diabetes and the control group but were significantly higher in the DM type 2 group. Both early diabetes and DM type 2 were associated with increased FBG, HbA1c, nesfatin-1, and insulin resistance, while adiponectin levels rose only in DM type 2. These findings suggest adiponectin as a potential biomarker for DM type 2, while nesfatin-1 may aid early diabetes diagnosis.
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| format | Article |
| id | doaj-art-c12bdd0097be4d40adfe42199b80d064 |
| institution | DOAJ |
| issn | 1978-3019 2086-4094 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Bogor Agricultural University |
| record_format | Article |
| series | Hayati Journal of Biosciences |
| spelling | doaj-art-c12bdd0097be4d40adfe42199b80d0642025-08-20T03:10:31ZengBogor Agricultural UniversityHayati Journal of Biosciences1978-30192086-40942025-03-0132410.4308/hjb.32.4.980-988Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetesAbdullah Abdulsattar Raeef0Mohammed Hashim Mohammed1Jwan Najm Abdullah2Department of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar 31001, IraqDepartment of Medical Laboratories Techniques, College of Health and Medical Technology, University of Al Maarif, Al Anbar 31001, IraqCollege of Science, Al-karkh University of Science, Baghdad, Iraq Pre-diabetes is characterized by elevated blood sugar levels that are not yet high enough for a Type 2 diabetes diagnosis. Type 2 diabetes results from insufficient insulin production or cellular resistance to insulin. Adiponectin, secreted by adipose tissue, regulates glucose metabolism and energy balance, while nesfatin-1, derived from NUCB2, influences appetite and energy homeostasis. This case-control study at Al-Ramadi Teaching Hospital included 80 participants with diabetes mellitus (DM) or early-stage DM and 40 healthy controls. Demographic data, including age, Body mass index (BMI), and disease duration, were collected. Laboratory tests measured fasting blood glucose (FBG), Glycated hemoglobin (HbA1c%), insulin, adiponectin, and nesfatin-1 levels. Statistical analyses, including ANOVA, Pearson’s correlation, and AUC analysis, assessed relationships and diagnostic accuracy. Results showed significantly higher levels of FBG, HbA1c, insulin resistance, and nesfatin-1 in early diabetes and DM type 2 cases compared to healthy controls. Nesfatin-1 concentrations were also notably higher in early diabetes compared to other groups. Adiponectin levels did not significantly differ between early diabetes and the control group but were significantly higher in the DM type 2 group. Both early diabetes and DM type 2 were associated with increased FBG, HbA1c, nesfatin-1, and insulin resistance, while adiponectin levels rose only in DM type 2. These findings suggest adiponectin as a potential biomarker for DM type 2, while nesfatin-1 may aid early diabetes diagnosis. https://journal.ipb.ac.id/index.php/hayati/article/view/59539 |
| spellingShingle | Abdullah Abdulsattar Raeef Mohammed Hashim Mohammed Jwan Najm Abdullah Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes Hayati Journal of Biosciences |
| title | Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes |
| title_full | Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes |
| title_fullStr | Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes |
| title_full_unstemmed | Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes |
| title_short | Assessment of the Influence of Adiponectin, Nesfatin-1, Insulin Resistance, and Various Biochemical Parameters in Samples of Iraqi Individuals Diagnosed with Type 2 Diabetes Mellitus and Pre-diabetes |
| title_sort | assessment of the influence of adiponectin nesfatin 1 insulin resistance and various biochemical parameters in samples of iraqi individuals diagnosed with type 2 diabetes mellitus and pre diabetes |
| url | https://journal.ipb.ac.id/index.php/hayati/article/view/59539 |
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