Effects of functional antioxidants on the expansion of gamma delta T-cells and their cellular cytotoxicity against bladder cancer cells

Effects of functional antioxidants on the expansion of gamma delta T-cells and their cellular cytotoxicity against bladder cancer cells

Abstract Purpose Results of previous studies have demonstrated that T-cell receptor cross-linking rapidly generates reactive oxygen species, which play essential signaling roles within mitochondria for the antigen-specific expansion of T-cells. However, oxidative stress also causes damage to cellula...

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Main Authors: Yueh Pan, Hung-Jen Shih, Shu-Han Chuang, Chin-Pao Chang, Chi-Hao Hsiao, Ya-Hsu Chiu, Pai-Fu Wang, Chi-Chen Lin, Ping-Hsiao Shih
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cancer
Subjects:
Adoptive T-cell therapy
Γδ T-cell
Oxidative stress
Multi-functional antioxidant
Urothelial carcinoma of the bladder
Cytolysis
Online Access:https://doi.org/10.1186/s12885-025-14383-7
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