Heterogeneity in the Histopathological Features of Cystic Lesions of the Kidney with Special Reference to CK7 IHC in Cystic Renal Tumours: A Cross-sectional Study from a Tertiary Care Centre
Introduction: Renal cystic lesions are the most commonly encountered kidney pathologies, which can fall into developmental, acquired, genetic, infectious and neoplastic categories. Prompt histological diagnosis, in co-ordination with radiological findings, is very important for the further managemen...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2025-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/20770/74532_CE(Ra1)_F(Sh)_QC(PS_SS)_PF1(JY_OM)_PFA(IS)_PB(JY_IS)_PN(IS).pdf |
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| Summary: | Introduction: Renal cystic lesions are the most commonly encountered kidney pathologies, which can fall into developmental, acquired, genetic, infectious and neoplastic categories. Prompt histological diagnosis, in co-ordination with radiological findings, is very important for the further management of these lesions.
Aim: To study the histopathological features of renal cystic lesions and to examine the immunological expression of Cytokeratin 7 (CK7) in cystic renal tumours.
Materials and Methods: The present study is a cross-sectional study conducted in the Department of Pathology, Narayana Medical college, Nellore, Andhra Pradesh, India. Study was conducted over a period of five years, from June 2018 to May 2023, both prospectively and retrospectively. It includes 38 cases of cystic renal lesions out of 147 kidney specimens, which included cyst walls and nephrectomy specimens. Out of the 38 cystic renal lesions, 11 cases of cystic renal tumours were identified. Cytokeratin 7 Immunohistochemistry (IHC) was performed on these 11 cases of cystic renal tumours. Only diffuse membranous or cytoplasmic immunostaining in tumour cells is considered positive, while weak or focal immunostaining is considered negative. The data was entered into Microsoft (MS) Excel sheet and descriptive measures obtained included frequencies and percentages.
Results: Among the 38 cases of cystic renal lesions, the most common were 17 cases of simple cysts, followed by 10 cases of clear cell renal cell carcinoma with a cystic component, three cases of acquired cystic disease, three cases of renal dysplasia, two cases of hydatid cyst, one case of mucinous cyst, one case of adult polycystic kidney disease and one case of a cystic renal neoplasm of low malignant potential. All 11 cases of cystic renal tumours exhibited clear cell morphology. Cytokeratin 7 immunostaining was performed on the 11 cases of cystic renal tumours, of which only the lining cells in a single case of cystic renal neoplasm of low malignant potential showed both intense and diffuse cytoplasmic positivity. The remaining 10 cases of clear cell Renal Cell Carcinoma (RCC) were negative, showing no immunoreactivity.
Conclusion: Renal cystic lesions encompass a broad range of pathologies that have many overlapping features on histopathology. The use of immunohistochemical markers aids in differentiating low malignant potential cystic renal tumours from malignant ones. |
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| ISSN: | 2249-782X 0973-709X |